Anti-Scavenger Receptor BI + BII antibody (ab36970)


  • Product name
    Anti-Scavenger Receptor BI + BII antibody
  • Description
    Rabbit polyclonal to Scavenger Receptor BI + BII
  • Host species
  • Specificity
    ab36970 is specific for SR-BI and SR-BII.
  • Tested applications
    Suitable for: WB, ICC/IF, IP, Blockingmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide, corresponding to extracellular amino acids 230-280 of Scavenger Receptor BI + BII

  • Positive control
    • Tissues that express SR-BI and/or SR-BII such as such as liver, ovary, adrenal glands, and to as lesser extent testes, heart and mammary glands.


Our Abpromise guarantee covers the use of ab36970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 82 kDa.
ICC/IF 1/1000.
IP 1/100.
Blocking 1/100.


  • Relevance
    High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
  • Cellular localization
    Lysosome; lysosomal membrane; multi-pass membrane protein.
  • Database links
  • Alternative names
    • CD36 and LIMPII Analogous 1 antibody
    • CD36L1 antibody
    • CD36L2 antibody
    • CLA1 antibody
    • HLGP85 antibody
    • LGP85 antibody
    • LIMP II antibody
    • SCARB1 antibody
    • SCARB2 antibody
    • Scavenger receptor class B member 2 antibody
    • Scavenger Receptor Class B Type I antibody
    • SRBI antibody
    • SRBII antibody
    see all


  • All lanes : Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution

    Lane 1 : wild-type mice
    Lane 2 : SR-BI deficient mice

    Predicted band size: 82 kDa

  • Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution + 80 µg of total mouse liver lysates

    Predicted band size: 82 kDa


This product has been referenced in:
  • Balasubramanian K  et al. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal 8:ra95 (2015). Read more (PubMed: 26396268) »
  • Badeau RM  et al. Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters. J Steroid Biochem Mol Biol 116:44-9 (2009). Blocking ; Human . Read more (PubMed: 19406243) »

See all 3 Publications for this product

Customer reviews and Q&As

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