Overview

  • Product name
    Anti-Scavenging Receptor SR-BI antibody
    See all Scavenging Receptor SR-BI primary antibodies
  • Description
    Rabbit polyclonal to Scavenging Receptor SR-BI
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid peptide near the amino terminus of Human Scavenging Receptor SR-BI.

  • Positive control
    • WB: Human spleen tissue lysate IHC-P: Human spleen tissue

Applications

Our Abpromise guarantee covers the use of ab106572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function
    Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the CD36 family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell membrane. Membrane > caveola. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD36 and LIMPII analogous 1 antibody
    • CD36 antibody
    • CD36 Antigen like 1 antibody
    • CD36 antigen-like 1 antibody
    • CD36L1 antibody
    • CLA 1 antibody
    • CLA-1 antibody
    • CLA1 antibody
    • Collagen type I receptor antibody
    • HDLQTL6 antibody
    • MGC138242 antibody
    • SCARB1 antibody
    • Scavebger Receptor Class B Member 1 antibody
    • Scavenger receptor class B member 1 antibody
    • Scavenger Receptor Class B Type 1 antibody
    • SCRB1_HUMAN antibody
    • SR BI antibody
    • SR-BI antibody
    • SRB1 antibody
    • SRBI antibody
    • Thrombospondin receptor like 1 antibody
    • thrombospondin receptor-like 1 antibody
    see all

Images

  • Lane 1 : Anti-Scavenging Receptor SR-BI antibody (ab106572) at 1 µg/ml
    Lane 2 : Anti-Scavenging Receptor SR-BI antibody (ab106572) at 2 µg/ml

    All lanes : Human spleen tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 61 kDa

  • Immunohistochemical analysis of Scavenging Receptor SR-BI in paraffin embedded Human spleen tissue sections, using ab106572 at 2.5 µg/ml.
  • Immunofluorescence of SCARB1 in Human Spleen cells using ab106572 at 20 ug/ml.

References

This product has been referenced in:
  • Hu J  et al. Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF-?B activation in T cells. Biomed Pharmacother 102:271-277 (2018). Read more (PubMed: 29567540) »
  • Sa-Ngiamsuntorn K  et al. A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host. Virol J 13:59 (2016). Read more (PubMed: 27044429) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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