Overview

  • Product name

    Anti-Scavenging Receptor SR-BI antibody [G4H10]
    See all Scavenging Receptor SR-BI primary antibodies
  • Description

    Rabbit monoclonal [G4H10] to Scavenging Receptor SR-BI
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human Scavenging Receptor SR-BI aa 88-100.
    Sequence:

    ERGPYVYREFRHK(c)


    Database link: Q8WTV0

  • Positive control

    • WB: HepG2 cell extract; Mouse liver extract. IHC-P: Human liver and spleen tissues; Mouse liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 60 kDa.

Target

  • Function

    Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the CD36 family.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Cell membrane. Membrane > caveola. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD36 and LIMPII analogous 1 antibody
    • CD36 antibody
    • CD36 Antigen like 1 antibody
    • CD36 antigen-like 1 antibody
    • CD36L1 antibody
    • CLA 1 antibody
    • CLA-1 antibody
    • CLA1 antibody
    • Collagen type I receptor antibody
    • HDLQTL6 antibody
    • MGC138242 antibody
    • SCARB1 antibody
    • Scavebger Receptor Class B Member 1 antibody
    • Scavenger receptor class B member 1 antibody
    • Scavenger Receptor Class B Type 1 antibody
    • SCRB1_HUMAN antibody
    • SR BI antibody
    • SR-BI antibody
    • SRB1 antibody
    • SRBI antibody
    • Thrombospondin receptor like 1 antibody
    • thrombospondin receptor-like 1 antibody
    see all

Images

  • Paraffin-embedded mouse liver tissue stained for Scavenging Receptor SR-BI using ab238517 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human liver tissue stained for Scavenging Receptor SR-BI using ab238517 at 1/100 dilution in immunohistochemical analysis.

  • All lanes : Anti-Scavenging Receptor SR-BI antibody [G4H10] (ab238517) at 1/500 dilution

    Lane 1 : HepG2 (human liver hepatocellular carcinoma cell line) cell extract
    Lane 2 : Mouse liver extract

    Lysates/proteins at 25 µg per lane.

    Secondary
    All lanes : HRP Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution

    Predicted band size: 60 kDa



    Blocking buffer: 3% non-fat dry milk in TBST

  • Paraffin-embedded human spleen tissue stained for Scavenging Receptor SR-BI using ab238517 at 1/100 dilution in immunohistochemical analysis.

References

ab238517 has not yet been referenced specifically in any publications.

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