Anti-SCD1 antibody [CD.E10] (ab19862)

Mouse monoclonal SCD1 antibody [CD.E10]. Validated in WB, IP, ELISA, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 33 publication(s). Independently reviewed in 6 review(s).

Publishing research using ab19862? Please let us know so that we can cite the reference in this datasheet.

ab19862 has been referenced in 33 publications.

  • Xu MX  et al. Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia. Free Radic Biol Med 130:542-556 (2019). PubMed: 30465824
  • Li CC  et al. 14-Deoxy-11,12-didehydroandrographolide suppresses adipogenesis of 3 T3-L1 preadipocytes by inhibiting CCAAT/enhancer-binding protein ß activation and AMPK-mediated mitotic clonal expansion. Toxicol Appl Pharmacol 359:82-90 (2018). PubMed: 30248417
  • Sanchez DJ  et al. PPAR? is dispensable for clear cell renal cell carcinoma progression. Mol Metab N/A:N/A (2018). WB ; Human . PubMed: 29866440
  • Xie H  et al. IRE1a RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest 128:1300-1316 (2018). PubMed: 29381485
  • Paiardi C  et al. The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival. Genes (Basel) 8:N/A (2017). PubMed: 28452935
  • Wu G  et al. Menin enhances c-Myc-mediated transcription to promote cancer progression. Nat Commun 8:15278 (2017). WB ; Human . PubMed: 28474697
  • Colacino JA  et al. Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Res Treat 158:29-41 (2016). PubMed: 27306423
  • Silvers WC  et al. Design, radiosynthesis, and evaluation of radiotracers for positron emission tomography imaging of stearoyl-CoA desaturase-1. Bioorg Med Chem Lett 26:924-927 (2016). PubMed: 26778147
  • Wang J  et al. High Expression of Stearoyl-CoA Desaturase 1 Predicts Poor Prognosis in Patients with Clear-Cell Renal Cell Carcinoma. PLoS One 11:e0166231 (2016). IHC ; Human . PubMed: 27861513
  • Belkaid A  et al. 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells. BMC Cancer 15:440 (2015). WB, ICC . PubMed: 26022099
  • Southam AD  et al. Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids. Cancer Res 75:2530-40 (2015). PubMed: 25943877
  • Zhang X  et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal 22:848-70 (2015). PubMed: 25602171
  • Nanjappa V  et al. Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes. Cancer Biol Ther 16:1593-603 (2015). PubMed: 26391970
  • Clingman CC  et al. Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite. Elife 3:N/A (2014). WB ; Rat . PubMed: 24935936
  • Lu Y  et al. Overexpression of stearoyl-CoA desaturase 1 in bone marrow mesenchymal stem cells enhance the expression of induced endothelial cells. Lipids Health Dis 13:53 (2014). WB . PubMed: 24650127
  • Wang C  et al. Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db/db mice. PLoS One 9:e101315 (2014). WB . PubMed: 24983750
  • Rojas C  et al. Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells. PLoS One 9:e113929 (2014). PubMed: 25436452
  • Benatti RO  et al. Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring. Br J Nutr 111:2112-22 (2014). PubMed: 24666709
  • Marks KA  et al. Hepatic and plasma sex differences in saturated and monounsaturated fatty acids are associated with differences in expression of elongase 6, but not stearoyl-CoA desaturase in Sprague-Dawley rats. Genes Nutr 8:317-27 (2013). WB ; Rat . PubMed: 23180365
  • Muir K  et al. Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. Cancer Res 73:4722-31 (2013). PubMed: 23749645
  • Robichaud PP  et al. Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells. J Lipid Res 54:2665-77 (2013). Human . PubMed: 23894206
  • Eckle T  et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18:774-82 (2012). PubMed: 22504483
  • Yu Y  et al. Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. J Virol 86:2942-9 (2012). WB ; Human . PubMed: 22258239
  • Ehara T  et al. Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Diabetes 61:2442-50 (2012). WB . PubMed: 22721968
  • Yoshihara D  et al. Global Gene Expression Profiling in PPAR-? Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease. PPAR Res 2012:695898 (2012). IHC . PubMed: 22666229
  • Rivas DA  et al. Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle. Acta Physiol (Oxf) 202:691-701 (2011). PubMed: 21439027
  • Ecker J  et al. Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. Proc Natl Acad Sci U S A 107:7817-22 (2010). WB ; Mouse . PubMed: 20385828
  • Fritz V  et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 9:1740-54 (2010). ICC/IF, IHC-P ; Human . PubMed: 20530718
  • Ecker J  et al. Lower SCD expression in dendritic cells compared to macrophages leads to membrane lipids with less mono-unsaturated fatty acids. Immunobiology 215:748-55 (2010). PubMed: 20579763
  • Hellemans KH  et al. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS One 4:e7266 (2009). WB ; Rat . PubMed: 19787047
  • Peter A  et al. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58:1757-65 (2009). PubMed: 19478146
  • Peter A  et al. Induction of stearoyl-CoA desaturase (SCD-1) protects human arterial endothelial cells against lipotoxicity. Am J Physiol Endocrinol Metab : (2008). PubMed: 18523127
  • Yao-Borengasser A  et al. Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness. J Clin Endocrinol Metab 93:4431-9 (2008). WB ; Human . PubMed: 18697866


Sign up