Overview

  • Product name

    SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor
  • Description

    Potent, selective SCD1(stearoyl-CoA desaturase 1) inhibitor
  • Biological description

    Potent, selective SCD1 (stearoyl-CoA desaturase 1) inhibitor (IC50 = 4.5 nM). Inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in vitro, when heptadecanoic acid and palmitic acid are used as the substrate (IC50 = 7.9 and 6.8 nM, respectively). Active in vivo. Orally bioavailable.
  • Purity

    > 99%
  • CAS Number

    1032229-33-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
  • Molecular weight

    387.87
  • Molecular formula

    C20H22ClN3O3
  • PubChem identifier

    24905400
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Uto Y  et al. Discovery of novel SCD1 inhibitors: 5-alkyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] analogs. Eur J Med Chem 46:1892-6 (2011). Read more (PubMed: 21356569) »
  • Issandou M  et al. Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models. Eur J Pharmacol 618:28-36 (2009). Read more (PubMed: 19616540) »
  • Xin Z  et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett 18:4298-302 (2008). Read more (PubMed: 18632269) »
See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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