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Signal Transduction Metabolism Lipid metabolism
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SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor (ab142089)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor (ab142089)

    Key features and details

    • Potent, selective SCD1(stearoyl-CoA desaturase 1) inhibitor
    • CAS Number: 1032229-33-6
    • Purity: > 99%
    • Soluble in ethanol to 10 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor
    • Description

      Potent, selective SCD1(stearoyl-CoA desaturase 1) inhibitor
    • Biological description

      Potent, selective SCD1 (stearoyl-CoA desaturase 1) inhibitor (IC50 = 4.5 nM). Inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in vitro, when heptadecanoic acid and palmitic acid are used as the substrate (IC50 = 7.9 and 6.8 nM, respectively). Active in vivo. Orally bioavailable.

    • Purity

      > 99%
    • CAS Number

      1032229-33-6
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
    • Molecular weight

      387.87
    • Molecular formula

      C20H22ClN3O3
    • PubChem identifier

      24905400
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in ethanol to 10 mM and in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Metabolism
      • Lipid metabolism
      • Cardiovascular
      • Lipids / Lipoproteins
      • Fatty Acids
      • Metabolism
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Metabolism of lipids and lipoproteins
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Signaling
      • Lipid signaling
      • Fatty acid synthase
      • Inhibitors
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Fatty acids
      • Metabolism
      • Types of disease
      • Obesity
      • Metabolism
      • Pathways and Processes
      • Redox metabolism
      • Fatty acid oxidation

    Associated products

      Images

      • Chemical Structure - SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor (ab142089)
        Chemical Structure - SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor (ab142089)
        2D chemical structure image of ab142089, SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download
      • COA

      References (4)

      Publishing research using ab142089? Please let us know so that we can cite the reference in this datasheet.

      ab142089 has been referenced in 4 publications.

      • Zhang Q  et al. Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress. J Exp Clin Cancer Res 38:116 (2019). PubMed: 30845964
      • Fanning S  et al. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell 73:1001-1014.e8 (2019). PubMed: 30527540
      • Sinha RA  et al. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy 13:169-186 (2017). WB ; Mouse . PubMed: 27846372
      • Southam AD  et al. Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids. Cancer Res 75:2530-40 (2015). PubMed: 25943877

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