Overview

  • Product name

    SCH-202676, GPCR allosteric modulator
  • Description

    Non-selective GPCR allosteric modulator
  • Biological description

    Non-selective GPCR allosteric modulator. Inhibits adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM). Inhibits agonist and antagonist binding to GPCRs.
  • Purity

    > 98%
  • CAS Number

    70375-43-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
  • Molecular weight

    348.26
  • Molecular formula

    C15H13N3S.HBr
  • PubChem identifier

    11957689
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN=C1N=C(N(S1)C2=CC=CC=C2)C3=CC=CC=C3.Br
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lewandowicz AM  et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol 147:422-9 (2006). Read more (PubMed: 16402041) »
  • Gao ZG  et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci 74:3173-80 (2004). Read more (PubMed: 15081581) »
  • Fawzi AB  et al. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol Pharmacol 59:30-7 (2001). Read more (PubMed: 11125021) »

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