Potent, highly selective A2A receptor antagonist. (Ki values are 1-2, 289 and >10000 nM at A2A, A1 and A3 receptors, respectively). Displays therapeutic effects in animal Parkinson's models and elicits locomotor sensitization in vivo.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Hsu CW et al. Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice. J Biomed Sci17:4 (2010).
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Kelsey JE et al. The effects of systemic, intrastriatal, and intrapallidal injections of caffeine and systemic injections of A2A and A1 antagonists on forepaw stepping in the unilateral 6-OHDA-lesioned rat. Psychopharmacology (Berl)201:529-39 (2009).
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Shah U et al. Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists. Bioorg Med Chem Lett18:4204-9 (2008).
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