Overview

  • Product name

  • Description

    Rabbit polyclonal to SCN11A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SCN11A (internal sequence). NP_054858.2.
    Database link: Q9UI33

  • Positive control

    • Human cervical cancer and lung cancer tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198859 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
  • Tissue specificity

    Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
  • Involvement in disease

    Neuropathy, hereditary sensory and autonomic, 7
    Episodic pain syndrome, familial, 3
  • Sequence similarities

    Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.
  • Domain

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications

    Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • hNaN antibody
    • NaN antibody
    • NAV1.9 antibody
    • Peripheral nerve sodium channel 5 antibody
    • PN 5 antibody
    • PN5 antibody
    • SCN 11A antibody
    • SCN 12A antibody
    • Scn11a antibody
    • SCN12A antibody
    • SCNBA_HUMAN antibody
    • Sensory neuron sodium channel 2 antibody
    • SNS 2 antibody
    • SNS2 antibody
    • Sodium channel protein type 11 subunit alpha antibody
    • Sodium channel protein type XI subunit alpha antibody
    • Sodium channel voltage gated type XI alpha antibody
    • Sodium channel voltage gated type XI alpha polypeptide antibody
    • Sodium channel voltage gated type XI alpha subunit antibody
    • Sodium channel voltage gated type XII alpha polypeptide antibody
    • Voltage gated sodium channel Nav1.9 antibody
    • Voltage gated sodium channel subunit alpha Nav1.9 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.9 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling SCN11A with ab198859 at 1/40 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling SCN11A with ab198859 at 1/40 dilution.

References

ab198859 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198859.
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