Anti-Scn1a antibody, prediluted (ab45058)


  • Product name
    Anti-Scn1a antibody, prediluted
    See all Scn1a primary antibodies
  • Description
    Rabbit polyclonal to Scn1a, prediluted
  • Host species
  • Specificity
    This antibody recognizes the alpha subunit of type I voltage-gated sodium channel.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Zebrafish
  • Immunogen

    Synthetic peptide within Rat Scn1a aa 1450-1550. The exact sequence is proprietary.

  • Positive control
    • Human cerebellum



Our Abpromise guarantee covers the use of ab45058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: Ready-to-use for 30 min at RT.

    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    • Involvement in disease
      Defects in SCN1A are the cause of generalized epilepsy with febrile seizures plus type 2 (GEFS+2) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
      Defects in SCN1A are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus.
      Defects in SCN1A are a cause of intractable childhood epilepsy with generalized tonic-clonic seizures (ICEGTC) [MIM:607208]. ICEGTC is a disorder characterized by generalized tonic-clonic seizures beginning usually in infancy and induced by fever. Seizures are associated with subsequent mental decline, as well as ataxia or hypotonia. ICEGTC is similar to SMEI, except for the absence of myoclonic seizures.
      Defects in SCN1A are the cause of migraine familial hemiplegic type 3 (FHM3) [MIM:609634]. FHM3 is an autosomal dominant severe subtype of migraine with aura characterized by some degree of hemiparesis during the attacks. The episodes are associated with variable features of nausea, vomiting, photophobia, and phonophobia. Age at onset ranges from 6 to 15 years. FHM is occasionally associated with other neurologic symptoms such as cerebellar ataxia or epileptic seizures. A unique eye phenotype of elicited repetitive daily blindness has also been reported to be cosegregating with FHM in a single Swiss family.
      Defects in SCN1A are the cause of familial febrile convulsions type 3A (FEB3A) [MIM:604403]; also known as familial febrile seizures 3. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
    • Sequence similarities
      Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily.
      Contains 1 IQ domain.
    • Domain
      The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • brain sodium channel type I antibody
      • EIEE6 antibody
      • FEB3 antibody
      • FEB3A antibody
      • FHM3 antibody
      • GEFS+2 antibody
      • GEFSP2 antibody
      • HBSC I antibody
      • HBSCI antibody
      • NAC1 antibody
      • Nav 1.1 antibody
      • RBI antibody
      • SCN1 antibody
      • Scn1a antibody
      • SCN1A_HUMAN antibody
      • SMEI antibody
      • Sodium channel protein brain I alpha subunit antibody
      • Sodium channel protein brain I subunit alpha antibody
      • Sodium channel protein type 1 subunit alpha antibody
      • Sodium channel protein type I subunit alpha antibody
      • Sodium channel voltage gated type 1 alpha subunit antibody
      • Sodium channel voltage gated type I alpha polypeptide antibody
      • Voltage-gated sodium channel subunit alpha Nav1.1 antibody
      see all


    • Ab45058 staining human Voltage gated sodium channel type I in human cerebellum by immunohistochemistry using formalin fixed, paraffin embedded tissue.


    ab45058 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for getting back to me. I'm glad you found the information provided useful.
    As you have found, the immunogen used to raise ab24820 shares 100% homology with the sequence you provided (NP_001038360.1), please see the attachment.
    I th...

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    Thank you for getting back to me with this information.
    We have not tested any of our anti-Scn1a antibodies in Zebrafish. I have now checked if any of our other antibodies directed against this target are likely to be able to detect the Zebrafish ...

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    Thank you for contacting us and your interest in our products.
    You correct in thinking that the Anti-Scn1a antibody (ab45058) has as yet not been tested in western blotting. This does not mean that it would not work in this application, simply tha...

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