• Product name

  • Description

    Rabbit polyclonal to SCN1B
  • Host species

  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 70-98 of Human SCN1B (NP_950238.1, NP_001028.1).

  • Positive control

    • Mouse Neuro-2a cell line lysates and Human brain tissue. This antibody gave a positive result when used in the following formaldehyde fixed cell lines: HepG2



Our Abpromise guarantee covers the use of ab107370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 µg/ml.
WB 1/100 - 1/500. Predicted molecular weight: 25 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • Tissue specificity

    Abundantly expressed in skeletal muscle, heart and brain.
  • Involvement in disease

    Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in SCN1B are the cause of Brugada syndrome type 5 (BRS5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • Sequence similarities

    Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • GEFSP1 antibody
    • SCN1B antibody
    • SCN1B_HUMAN antibody
    • sodium channel beta 1 subunit antibody
    • Sodium channel subunit beta 1 antibody
    • Sodium channel subunit beta-1 antibody
    • Sodium channel voltage gated type I beta antibody
    • Sodium channel voltage gated type I beta subunit antibody
    see all


  • Anti-SCN1B antibody (ab107370) at 1/100 dilution + Mouse Neuro-2a cell line lysates at 35 µg

    Predicted band size: 25 kDa

  • ICC/IF image of ab107370 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab107370 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

  • ab107370 at 1/50 dilution staining SCN1B in formalin-fixed and paraffin-embedded Human brain tissue by Immunohistochemistry, followed by peroxidase conjugation of the secondary antibody and DAB detection.


This product has been referenced in:

  • Shimizu H  et al. Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel ß subunits. Sci Rep 6:26618 (2016). Read more (PubMed: 27216889) »
See 1 Publication for this product

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