Overview

  • Product name

  • Description

    Rabbit polyclonal to SCN3A
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Guinea pig, Cow, Chimpanzee, Monkey, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human SCN3A (internal sequence). 18 amino acids. NP_008853.3.
    Database link: Q9NY46

  • Positive control

    • Human brain, cerebellum tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 15 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  • Sequence similarities

    Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.
    Contains 1 IQ domain.
  • Domain

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications

    May be ubiquitinated by NEDD4L; which would promote its endocytosis.
    Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • brain III voltage-gated sodium channel antibody
    • NAC3 antibody
    • Nav1.3 antibody
    • SCN3A antibody
    • SCN3A_HUMAN antibody
    • Sodium channel protein brain III subunit alpha antibody
    • Sodium channel protein type 3 subunit alpha antibody
    • Sodium channel protein type III subunit alpha antibody
    • Sodium channel protein, brain III subunit alpha antibody
    • sodium channel, brain type III, alpha subunit antibody
    • sodium channel, neuronal type III, alpha subunit antibody
    • sodium channel, voltage-gated, type III, alpha polypeptide antibody
    • sodium channel, voltage-gated, type III, alpha subunit antibody
    • Voltage gated sodium channel subtype III antibody
    • Voltage gated sodium channel subunit alpha Nav1.3 antibody
    • Voltage-gated sodium channel subtype III antibody
    • Voltage-gated sodium channel subunit alpha Nav1.3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cerebellum tissue, labeling SCN3A with ab188801 at 20 µg/ml.

References

ab188801 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188801.
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