Key features and details
- Rabbit polyclonal to SCN3A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SCN3A antibody
See all SCN3A primary antibodies
DescriptionRabbit polyclonal to SCN3A
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Guinea pig, Cow, Chimpanzee, Monkey, Common marmoset, Orangutan
Synthetic peptide corresponding to Human SCN3A (internal sequence). 18 amino acids. NP_008853.3.
Database link: Q9NY46
- Human brain, cerebellum tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab188801 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 15 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.
Contains 1 IQ domain.
DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
modificationsMay be ubiquitinated by NEDD4L; which would promote its endocytosis.
Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
- Information by UniProt
- brain III voltage-gated sodium channel antibody
- NAC3 antibody
- Nav1.3 antibody
ab188801 has not yet been referenced specifically in any publications.