Key features and details
- Rabbit polyclonal to SCN4B
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SCN4B antibody
See all SCN4B primary antibodies
DescriptionRabbit polyclonal to SCN4B
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide within Human SCN4B aa 61-110. The exact sequence is proprietary.
Database link: Q8IWT1
- IHC-P: Human prostate and colon tissue. WB: HepG2 and Jurkat cell lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab219816 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 25 kDa.|
RelevanceThe SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation By similarity. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
Cellular localizationCell Membrane
- SCN4B_HUMAN antibody
- Sodium channel subunit beta-4 antibody
Immunohistochemical analysis of paraffin embedded formalin fixed human prostate issue labeling SCN4B using ab219816 at 1/100 dilution.
Immunohistochemical analysis of paraffin embedded formalin fixed human colon issue labeling SCN4B using ab219816 at 1/100 dilution.
All lanes : Anti-SCN4B antibody (ab219816) at 1/500 dilution
Lane 1 : HepG2 cell lysate
Lane 2 : Jurkat cell lysate
Lane 3 : HepG2 cell lysate with synthesized peptide
Predicted band size: 25 kDa
ab219816 has not yet been referenced specifically in any publications.