Overview

  • Product name

  • Description

    Rabbit polyclonal to SCN4B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human SCN4B aa 61-110. The exact sequence is proprietary.
    Database link: Q8IWT1

  • Positive control

    • IHC-P: Human prostate and colon tissue. WB: HepG2 and Jurkat cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab219816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 25 kDa.
IHC-P 1/100.

Target

  • Relevance

    The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation By similarity. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
  • Cellular localization

    Cell Membrane
  • Database links

  • Alternative names

    • SCN4B_HUMAN antibody
    • Sodium channel subunit beta-4 antibody

Images

  • Immunohistochemical analysis of paraffin embedded formalin fixed human prostate issue labeling SCN4B using ab219816 at 1/100 dilution.

  • Immunohistochemical analysis of paraffin embedded formalin fixed human colon issue labeling SCN4B using ab219816 at 1/100 dilution.

  • All lanes : Anti-SCN4B antibody (ab219816) at 1/500 dilution

    Lane 1 : HepG2 cell lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : HepG2 cell lysate with synthesized peptide

    Predicted band size: 25 kDa

References

ab219816 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab219816.
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