Overview

  • Product name

    Anti-SCNN1B antibody [7B8] - C-terminal
    See all SCNN1B primary antibodies
  • Description

    Mouse monoclonal [7B8] to SCNN1B - C-terminal
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Rat SCNN1B aa 617-638 (C terminal). NP_036780
    Sequence:

    NYDSLRLQPLDTMESDSEVEAI


    Database link: P37090

  • Positive control

    • IHC-P: Mouse kidney cortex tissue. WB: Mouse kidney homogenates.

Properties

Applications

Our Abpromise guarantee covers the use of ab241050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 73 kDa.
IHC-P 1/50.

Target

  • Function

    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • Involvement in disease

    Pseudohypoaldosteronism 1, autosomal recessive
    Liddle syndrome
    Bronchiectasis with or without elevated sweat chloride 1
  • Sequence similarities

    Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
  • Post-translational
    modifications

    Phosphorylated on serine and threonine residues.
  • Cellular localization

    Apical cell membrane. Apical membrane of epithelial cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Amiloride sensitive sodium channel subunit beta antibody
    • Amiloride-sensitive sodium channel subunit beta antibody
    • Beta NaCH antibody
    • Beta-ENaC antibody
    • Beta-NaCH antibody
    • ENaC beta antibody
    • ENaCB antibody
    • Epithelial Na(+) channel subunit beta antibody
    • Epithelial Na+ channel beta subunit antibody
    • Epithelial Na+ channel subunit beta antibody
    • Epithelial sodium channel beta 2 subunit antibody
    • Epithelial sodium channel beta 3 subunit antibody
    • Nonvoltage gated sodium channel 1 beta subunit antibody
    • Nonvoltage gated sodium channel 1 subunit beta antibody
    • Nonvoltage-gated sodium channel 1 subunit beta antibody
    • SCNEB antibody
    • SCNN 1B antibody
    • SCNN1B antibody
    • SCNNB_HUMAN antibody
    • Sodium channel nonvoltage gated 1 beta (Liddle syndrome) antibody
    • Sodium channel nonvoltage gated 1 beta antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded mouse kidney cortex tissue stained for SCNN1B with ab241050 at 1/150 dilution in immunohistochemical analysis.

     

  • All lanes : Anti-SCNN1B antibody [7B8] - C-terminal (ab241050) at 1/1000 dilution

    Lane 1 : Mouse kidney homogenates from a mouse on a low-salt diet
    Lane 2 : Mouse kidney homogenates from a mouse on a normal salt diet

    Lysates/proteins at 20 µg per lane.

    Predicted band size: 73 kDa

References

ab241050 has not yet been referenced specifically in any publications.

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