Key features and details
- Rabbit polyclonal to SCNN1G
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SCNN1G antibody
See all SCNN1G primary antibodies
DescriptionRabbit polyclonal to SCNN1G
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Cow, Chimpanzee
- ICC/IF: RT4 cells.
This product was previously labelled as epithelial Sodium Channel gamma
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab222191 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
FunctionSodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Involvement in diseaseDefects in SCNN1G are a cause of Liddle syndrome (LIDDS) [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3) [MIM:613071]. A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.
Sequence similaritiesBelongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
modificationsPhosphorylated on serine and threonine residues.
Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.
Cellular localizationApical cell membrane. Apical membrane of epithelial cells.
- Information by UniProt
- Amiloride sensitive epithelial sodium channel gamma subunit antibody
- Amiloride sensitive sodium channel subunit gamma antibody
- Amiloride-sensitive sodium channel subunit gamma antibody
ab222191 has not yet been referenced specifically in any publications.