Overview

  • Product name
  • Description
    Mouse polyclonal to SCO2
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-266 of Human SCO2 (NP_005129.1).

  • Positive control
    • SCO2 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab169042 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.

Target

  • Function
    Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
  • Sequence similarities
    Belongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytochrome oxidase deficient homolog 2 antibody
    • MGC125823 antibody
    • MGC125825 antibody
    • OTTHUMP00000196774 antibody
    • OTTHUMP00000196775 antibody
    • Protein SCO2 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient, yeast) homolog 2 antibody
    • SCO 1L antibody
    • SCO 2 antibody
    • SCO cytochrome oxidase deficient homolog 2 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 2 antibody
    • SCO1L antibody
    • SCO2 antibody
    • SCO2_HUMAN antibody
    • Synthesis of cytochrome c oxidase 2 antibody
    see all

Images

  • All lanes : Anti-SCO2 antibody (ab169042) at 1 µg/ml

    Lane 1 : SCO2 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 30 kDa

References

This product has been referenced in:
  • Feng J  et al. Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20. J Virol 92:N/A (2018). Read more (PubMed: 29695422) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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