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    scp1-antibody-epr79192-ab184947.pdf

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Epigenetics and Nuclear Signaling Chromosome Structure Scaffold Proteins
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RecombinantRabMAb

Recombinant Anti-SCP1 antibody [EPR7919(2)] (ab184947)

  • Datasheet
  • Certificate of Compliance
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody [EPR7919(2)] (ab184947)
  • Anti-SCP1 antibody [EPR7919(2)] (ab184947)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR7919(2)] to SCP1
  • Suitable for: IHC-P
  • Reacts with: Human

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Overview

  • Product name

    Anti-SCP1 antibody [EPR7919(2)]
    See all SCP1 primary antibodies
  • Description

    Rabbit monoclonal [EPR7919(2)] to SCP1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • Human testis tissue.
  • General notes

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR7919(2)
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromosome Structure
    • Scaffold Proteins

Associated products

  • Alternative Versions

    • Anti-SCP1 antibody [EPR7919(2)] - BSA and Azide free (ab250786)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab184947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Notes
IHC-P
1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Target

  • Function

    Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.
  • Tissue specificity

    Testis.
  • Domain

    Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity.
  • Cellular localization

    Nucleus. Chromosome. In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex.
  • Target information above from: UniProt accession Q15431 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 6847 Human
    • Omim: 602162 Human
    • SwissProt: Q15431 Human
    • Unigene: 112743 Human
    • Alternative names

      • Cancer/testis antigen 8 antibody
      • CT8 antibody
      • HOM TES 14 antibody
      • MGC104417 antibody
      • SCP 1 antibody
      • SCP-1 antibody
      • SCP1 antibody
      • SYCP 1 antibody
      • Sycp1 antibody
      • SYCP1_HUMAN antibody
      • Synaptonemal complex protein 1 antibody
      • Testicular tissue protein Li 191 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody [EPR7919(2)] (ab184947)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody [EPR7919(2)] (ab184947)

      Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling SCP1 with ab184947 at 1/500 dilution. The slide is counterstained with Hematoxylin.

      Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

    • Anti-SCP1 antibody [EPR7919(2)] (ab184947)
      Anti-SCP1 antibody [EPR7919(2)] (ab184947)

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    Certificate of Compliance

    To download a Certificate of Compliance, please enter your Lot number below:

    References (1)

    Publishing research using ab184947? Please let us know so that we can cite the reference in this datasheet.

    ab184947 has been referenced in 1 publication.

    • Liu YB  et al. Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/ß-catenin signalling pathway. J Cell Mol Med 23:3855-3866 (2019). PubMed: 30955246

    Customer reviews and Q&As

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