Recombinant Anti-SCP1 antibody [EPR7919(2)] (ab184947)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7919(2)] to SCP1
- Suitable for: IHC-P
- Reacts with: Human
Overview
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Product name
Anti-SCP1 antibody [EPR7919(2)]
See all SCP1 primary antibodies -
Description
Rabbit monoclonal [EPR7919(2)] to SCP1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SCP1 aa 900 to the C-terminus. The exact sequence is proprietary.
Database link: Q15431 -
Positive control
- Human testis tissue.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol, 0.05% BSA -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR7919(2) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab184947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Target
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Function
Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. -
Tissue specificity
Testis. -
Domain
Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity. -
Cellular localization
Nucleus. Chromosome. In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex. - Information by UniProt
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Database links
- Entrez Gene: 6847 Human
- Omim: 602162 Human
- SwissProt: Q15431 Human
- Unigene: 112743 Human
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Alternative names
- Cancer/testis antigen 8 antibody
- CT8 antibody
- HOM TES 14 antibody
see all
Images
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody [EPR7919(2)] (ab184947)](https://www.abcam.com/ps/products/184/ab184947/Images/ab184947-217631-anti-scp1-antibody-epr79192-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody [EPR7919(2)] (ab184947)Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling SCP1 with ab184947 at 1/500 dilution. The slide is counterstained with Hematoxylin.
Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.
Datasheets and documents
Certificate of Compliance
References
ab184947 has been referenced in 1 publication.
- Liu YB et al. Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/ß-catenin signalling pathway. J Cell Mol Med 23:3855-3866 (2019). PubMed: 30955246
