Overview

  • Product name

  • Description

    Rabbit polyclonal to SCP3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-236 of Human SCP3 (Uniprot ID: Q8IZU3).

  • Positive control

    • Mouse testis whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab154255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.

Target

  • Function

    Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development.
  • Tissue specificity

    Testis-specific.
  • Involvement in disease

    Defects in SYCP3 are a cause of azoospermia due to perturbations of meiosis (AZSPM) [MIM:270960]. AZSPM is a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.
  • Sequence similarities

    Belongs to the XLR/SYCP3 family.
  • Cellular localization

    Nucleus. In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.
  • Information by UniProt
  • Database links

  • Alternative names

    • choline phosphotransferase 1 antibody
    • chpt1 antibody
    • COR 1 antibody
    • COR1 antibody
    • MGC71888 antibody
    • RNASCP3 antibody
    • SCP 3 antibody
    • SCP-3 antibody
    • SCP3 antibody
    • SPGF4 antibody
    • Sycp 3 antibody
    • Sycp3 antibody
    • SYCP3_HUMAN antibody
    • Synaptonemal complex protein 3 antibody
    see all

Images

  • Anti-SCP3 antibody (ab154255) at 1/1000 dilution + Mouse testis whole cell lysate at 50 µg

    Predicted band size: 28 kDa



    12% SDS PAGE

References

ab154255 has not yet been referenced specifically in any publications.

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