Overview

  • Product name

    SCR7 pyrazine, NHEJ inhibitor
  • Description

    Small molecule NHEJ inhibitor
  • Biological description

    Small molecule nonhomologous end-joining (NHEJ) inhibitor. SCR7 analog. Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro.

  • Purity

    > 98%
  • CAS Number

    14892-97-8

Properties

  • Chemical name

    2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
  • Molecular weight

    332.38
  • Molecular formula

    C18H12N4OS
  • PubChem identifier

    10688007
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4
  • Source

    Synthetic

References

This product has been referenced in:

  • Greco GE  et al. SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst) 43:18-23 (2016). Read more (PubMed: 27235626) »
  • Maruyama T  et al. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol 33:538-42 (2015). Read more (PubMed: 25798939) »
  • Chu VT  et al. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol 33:543-8 (2015). Read more (PubMed: 25803306) »
  • Srivastava M  et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell 151:1474-87 (2012). Read more (PubMed: 23260137) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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