Anti-SCUBE1 antibody (ab105358)
Key features and details
- Rabbit polyclonal to SCUBE1
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SCUBE1 antibody
See all SCUBE1 primary antibodies -
Description
Rabbit polyclonal to SCUBE1 -
Host species
Rabbit -
Specificity
ab105358 is predicted to not crossreact with other SCUBE members. -
Tested applications
Suitable for: WB, ICCmore details -
Species reactivity
Reacts with: Human -
Immunogen
A 14 amino acid peptide near the center of Human SCUBE1 (NP_766638).
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Positive control
- WB: Daudi cell lysate ICC: Daudi cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab105358 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa.
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ICC |
Use a concentration of 20 µg/ml.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa. |
ICC
Use a concentration of 20 µg/ml. |
Target
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Function
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. -
Tissue specificity
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferrred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques. -
Sequence similarities
Contains 1 CUB domain.
Contains 9 EGF-like domains. -
Post-translational
modificationsN-glycosylated.
Could be proteolytically cleaved to release a smaller active fragment. -
Cellular localization
Secreted. Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 80274 Human
- Omim: 611746 Human
- SwissProt: Q8IWY4 Human
- Unigene: 133995 Human
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Alternative names
- SCUB1_HUMAN antibody
- SCUBE 1 antibody
- SCUBE1 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab105358 has been referenced in 3 publications.
- Zhao J et al. CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma. J Transl Med 20:520 (2022). PubMed: 36348351
- Sun W et al. SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension. JACC Basic Transl Sci 5:1073-1092 (2020). PubMed: 33294740
- Del Valle I et al. A genomic atlas of human adrenal and gonad development. Wellcome Open Res 2:25 (2017). IHC ; Human . PubMed: 28459107