Overview

  • Product name

  • Description

    Rabbit polyclonal to SCYL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 328-552 of Human SCYL1

  • Positive control

    • A431, H1299 or HeLa cell lysates
      Paraformaldehyde fixed Hela cells
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab137639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 90 kDa.

Target

  • Function

    Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.
    Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Belongs to the protein kinase superfamily.
    Contains 3 HEAT repeats.
    Contains 1 protein kinase domain.
  • Domain

    The protein kinase domain is predicted to be catalytically inactive.
  • Cellular localization

    Nucleus; Cytoplasm > cytoskeleton > centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus > cis-Golgi network. Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner; Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner and Cytoplasm. Cytoplasmic throughout the cell cycle.
  • Information by UniProt
  • Database links

  • Alternative names

    • Coated vesicle associated kinase of 90 kDa antibody
    • Coated vesicle-associated kinase of 90 kDa antibody
    • CVAK90 antibody
    • GKLP antibody
    • HT019 antibody
    • Likely ortholog of mouse N terminal kinase like protein antibody
    • MGC78454 antibody
    • N terminal kinase like antibody
    • N terminal kinase like protein antibody
    • N-terminal kinase-like protein antibody
    • NKTL antibody
    • NTKL antibody
    • NTKL_HUMAN antibody
    • NTKLBP1 antibody
    • P105 antibody
    • SCY L1 antibody
    • SCY1 like 1 antibody
    • SCY1 like 1 protein 1 antibody
    • SCY1-like protein 1 antibody
    • SCYL 1 antibody
    • Scyl1 antibody
    • SCYL1BP1 antibody
    • TAPK antibody
    • TEIF antibody
    • Telomerase regulation associated protein antibody
    • Telomerase regulation-associated protein antibody
    • Telomerase transcriptional element interacting factor antibody
    • Telomerase transcriptional element-interacting factor antibody
    • Teratoma associated tyrosine kinase antibody
    • Teratoma-associated tyrosine kinase antibody
    • TRAP antibody
    see all

Images

  • Anti-SCYL1 antibody (ab137639) at 1/1000 dilution + Hela whole cell lysate at 30 µg

    Predicted band size: 90 kDa



    7.5% SDS PAGE
  • Confocal immunofluorescence analysis of paraformaldehyde fixed HeLa cells, labelling SCYL1 with ab137639 (Green) at 1/500 dilution. Alpha tubulin filaments were labelled with alpha tubulin antibody (Red) at 1/2500.

References

ab137639 has not yet been referenced specifically in any publications.

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