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    scyl1-antibody-ab229745.pdf

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Signal Transduction Protein Trafficking Vesicle Transport Coat Proteins
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Anti-SCYL1 antibody (ab229745)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCYL1 antibody (ab229745)

    Key features and details

    • Rabbit polyclonal to SCYL1
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human SCYL1 protein (ab135221)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-SCYL1 antibody
      See all SCYL1 primary antibodies
    • Description

      Rabbit polyclonal to SCYL1
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant fragment corresponding to Human SCYL1 aa 460-740.
      Database link: Q96KG9

    • Positive control

      • IHC-P: Human pancreatic tissue.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: PBS, 50% Glycerol (glycerin, glycerine)
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Protein Trafficking
      • Vesicle Transport
      • Coat Proteins
      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Other
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Other factors
      • Epigenetics and Nuclear Signaling
      • Chromatin Binding Proteins
      • DNA / RNA binding

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human SCYL1 protein (ab135221)

    Applications

    Our Abpromise guarantee covers the use of ab229745 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/20 - 1/200.

    Target

    • Function

      Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.
      Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
    • Tissue specificity

      Ubiquitous.
    • Sequence similarities

      Belongs to the protein kinase superfamily.
      Contains 3 HEAT repeats.
      Contains 1 protein kinase domain.
    • Domain

      The protein kinase domain is predicted to be catalytically inactive.
    • Cellular localization

      Nucleus; Cytoplasm > cytoskeleton > centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus > cis-Golgi network. Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner; Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner and Cytoplasm. Cytoplasmic throughout the cell cycle.
    • Target information above from: UniProt accession Q96KG9 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 57410 Human
      • Omim: 607982 Human
      • SwissProt: Q96KG9 Human
      • Unigene: 238839 Human
      • Alternative names

        • Coated vesicle associated kinase of 90 kDa antibody
        • Coated vesicle-associated kinase of 90 kDa antibody
        • CVAK90 antibody
        • GKLP antibody
        • HT019 antibody
        • Likely ortholog of mouse N terminal kinase like protein antibody
        • MGC78454 antibody
        • N terminal kinase like antibody
        • N terminal kinase like protein antibody
        • N-terminal kinase-like protein antibody
        • NKTL antibody
        • NTKL antibody
        • NTKL_HUMAN antibody
        • NTKLBP1 antibody
        • P105 antibody
        • SCY L1 antibody
        • SCY1 like 1 antibody
        • SCY1 like 1 protein 1 antibody
        • SCY1-like protein 1 antibody
        • SCYL 1 antibody
        • Scyl1 antibody
        • SCYL1BP1 antibody
        • TAPK antibody
        • TEIF antibody
        • Telomerase regulation associated protein antibody
        • Telomerase regulation-associated protein antibody
        • Telomerase transcriptional element interacting factor antibody
        • Telomerase transcriptional element-interacting factor antibody
        • Teratoma associated tyrosine kinase antibody
        • Teratoma-associated tyrosine kinase antibody
        • TRAP antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCYL1 antibody (ab229745)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCYL1 antibody (ab229745)

        Paraffin-embedded human pancreatic tissue stained for SCYL1 using ab229745 at 1/100 dilution in immunohistochemical analysis.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab229745? Please let us know so that we can cite the reference in this datasheet.

      ab229745 has not yet been referenced specifically in any publications.

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