• Product name
    SDHB peptide (271-280 )


  • Nature
  • Amino Acid Sequence
    • Species
    • Sequence
    • Amino acids
      271 to 280

Associated products


Our Abpromise guarantee covers the use of ab45793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SDHB antibody (ab39988)

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CWS2
    • FLJ92337
    • Ip
    • Iron sulfur subunit
    • Iron sulfur subunit of complex II
    • Iron-sulfur subunit of complex II
    • mitochondrial
    • PGL 4
    • PGL4
    • SDH
    • SDH 1
    • SDH1
    • SDH2
    • SDH2, homolog of
    • SdhB
    • SDHIP
    • Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial
    • Succinate dehydrogenase [ubiquinone] iron sulfur subunit
    • Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
    • succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    • Succinate Dehydrogenase 1 Iron Sulfur Subunit
    • Succinate Dehydrogenase 2, S. cerevisiae, homolog of
    • Succinate dehydrogenase complex iron sulfur subunit B
    • Succinate dehydrogenase complex subunit B iron sulfur
    • Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein
    • succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
    • Succinate dehydrogenase iron sulfur protein
    see all
  • Function
    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • Pathway
    Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
  • Involvement in disease
    Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
    Defects in SDHB are the cause of hereditary paragangliomas type 4 (PGL4) [MIM:115310]; also known as familial non-chromaffin paragangliomas type 4. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. PGL4 is characterized by the development of mostly benign, highly vascular, slow growing tumors in the head and neck. In the head and neck region, the carotid body is the largest of all paraganglia and is also the most common site of the tumors.
    Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
    Defects in SDHB are a cause of Cowden-like syndrome (CWDLS) [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.
  • Sequence similarities
    Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
    Contains 1 2Fe-2S ferredoxin-type domain.
    Contains 1 4Fe-4S ferredoxin-type domain.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt


ab45793 has not yet been referenced specifically in any publications.

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