Anti-SDS3 antibody (ab3740)

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Overview

  • Product name

    Anti-SDS3 antibody
    See all SDS3 primary antibodies

  • Description

    Goat polyclonal to SDS3

  • Host species

    Goat

  • Tested applications

    Suitable for: WB, IPmore details

  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Xenopus laevis, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis

  • Immunogen

    Synthetic peptide (Human) - which represented a portion of human Suppressor of Defective Silencing 3 encoded in part by exons 7 and 8.

  • Positive control

    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab3740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 45 kDa.
IP Use at an assay dependent dilution. PubMed: 21239494

Target

  • Function

    Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

  • Tissue specificity

    Expressed in various cancer cell ines.

  • Sequence similarities

    Belongs to the SDS3 family.

  • Domain

    The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • 2400003N08Rik antibody
    • 2410008L21Rik antibody
    • 45 kDa Sin3 associated polypeptide antibody
    • 45 kDa Sin3-associated polypeptide antibody
    • AU067672 antibody
    • FLJ00052 antibody
    • MGC104711 antibody
    • mSds3 antibody
    • RGD1305986 antibody
    • SAP45 antibody
    • SDS3 antibody
    • SDS3, yeast, homolog of antibody
    • SDS3_HUMAN antibody
    • Sin3 histone deacetylase corepressor complex component SDS3 antibody
    • Sin3A associated protein 45kDa antibody
    • Suds3 antibody
    • Suppressor of defective silencing 3 antibody
    • Suppressor of defective silencing 3 homolog (S cerevisiae) antibody
    • Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae) antibody
    • Suppressor of defective silencing 3 protein homolog antibody
    see all

Images

  • Western blot - Anti-SDS3 antibody (ab3740)
    Western blot - Anti-SDS3 antibody (ab3740)

    Sample: HeLa whole cell lysate (50µg/lane)

    Antibody: Affinity purified Goat anti-SDS 3 (ab3740) used at the concentrations indicated.

    Detection: ECL exposed for 2 minutes.

    Sample: HeLa whole cell lysate (50µg/lane)

    Antibody: Affinity purified Goat anti-SDS 3 (ab3740) used at the concentrations indicated.

    Detection: ECL exposed for 2 minutes.

References

This product has been referenced in:

  • Ramakrishna S  et al. Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity. PLoS One 7:e37772 (2012). WB ; Human . Read more (PubMed: 22662218) »
  • Ramakrishna S  et al. K63 specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J Biol Chem : (2011). IP ; Human . Read more (PubMed: 21239494) »
See all 2 Publications for this product

Publishing research using ab3740? Please let us know so that we can cite the reference in this datasheet.

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