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    sds3-antibody-ab3740.pdf

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Epigenetics and Nuclear Signaling Transcription Cancer susceptibility Tumor Suppressors
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Anti-SDS3 antibody (ab3740)

  • Datasheet
  • SDS
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Western blot - Anti-SDS3 antibody (ab3740)

    Key features and details

    • Goat polyclonal to SDS3
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Donkey Anti-Goat IgG H&L (HRP) (ab97110)

    View more associated products

    Overview

    • Product name

      Anti-SDS3 antibody
      See all SDS3 primary antibodies
    • Description

      Goat polyclonal to SDS3
    • Host species

      Goat
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide (Human) - which represented a portion of human Suppressor of Defective Silencing 3 encoded in part by exons 7 and 8.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7
      Preservative: 0.1% Sodium azide
      Constituents: 0.021% PBS, 1.764% Sodium citrate, 1.815% Tris
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
      • Tumor Suppressors
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Other factors
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Co-factors
      • Epigenetics and Nuclear Signaling
      • Chromatin Modifying Enzymes
      • Acetylation
      • HAT

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab3740 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    All applications
    Rabbit
    Chicken
    Guinea pig
    Cow
    Dog
    Turkey
    Pig
    Xenopus laevis
    Chimpanzee
    Zebrafish
    Rhesus monkey
    Gorilla
    Orangutan
    Xenopus tropicalis
    Application Abreviews Notes
    WB
    1/1000 - 1/5000. Predicted molecular weight: 45 kDa.
    Notes
    WB
    1/1000 - 1/5000. Predicted molecular weight: 45 kDa.

    Target

    • Function

      Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
    • Tissue specificity

      Expressed in various cancer cell ines.
    • Sequence similarities

      Belongs to the SDS3 family.
    • Domain

      The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
    • Target information above from: UniProt accession Q9H7L9 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 64426 Human
      • Entrez Gene: 445099 Zebrafish
      • Omim: 608250 Human
      • SwissProt: Q9H7L9 Human
      • SwissProt: Q803C3 Zebrafish
      • Unigene: 416630 Human
      • Unigene: 602312 Human
      • Alternative names

        • 2400003N08Rik antibody
        • 2410008L21Rik antibody
        • 45 kDa Sin3 associated polypeptide antibody
        • 45 kDa Sin3-associated polypeptide antibody
        • AU067672 antibody
        • FLJ00052 antibody
        • MGC104711 antibody
        • mSds3 antibody
        • RGD1305986 antibody
        • SAP45 antibody
        • SDS3 antibody
        • SDS3, yeast, homolog of antibody
        • SDS3_HUMAN antibody
        • Sin3 histone deacetylase corepressor complex component SDS3 antibody
        • Sin3A associated protein 45kDa antibody
        • Suds3 antibody
        • Suppressor of defective silencing 3 antibody
        • Suppressor of defective silencing 3 homolog (S cerevisiae) antibody
        • Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae) antibody
        • Suppressor of defective silencing 3 protein homolog antibody
        see all

      Images

      • Western blot - Anti-SDS3 antibody (ab3740)
        Western blot - Anti-SDS3 antibody (ab3740)

        Sample: HeLa whole cell lysate (50µg/lane)

        Antibody: Affinity purified Goat anti-SDS 3 (ab3740) used at the concentrations indicated.

        Detection: ECL exposed for 2 minutes.

        Sample: HeLa whole cell lysate (50µg/lane)

        Antibody: Affinity purified Goat anti-SDS 3 (ab3740) used at the concentrations indicated.

        Detection: ECL exposed for 2 minutes.

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (2)

      Publishing research using ab3740? Please let us know so that we can cite the reference in this datasheet.

      ab3740 has been referenced in 2 publications.

      • Ramakrishna S  et al. Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity. PLoS One 7:e37772 (2012). WB ; Human . PubMed: 22662218
      • Ramakrishna S  et al. K63 specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J Biol Chem : (2011). IP ; Human . PubMed: 21239494

      Customer reviews and Q&As

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