Product nameSEC23 peptide
See all SEC23 proteins and peptides
Amino Acid Sequence
SequenceAn 18 amino acid synthetic peptide whose sequences are derived from rat COP II protein. The sequence of this peptide is (amino to carboxy terminus): M(1)TTYLEFIQQNEERDGVR(18) - C.
Our Abpromise guarantee covers the use of ab4960 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat COP II, catalog ab3351. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
- Protein transport protein Sec23A
FunctionComponent of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
Involvement in diseaseDefects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.
Sequence similaritiesBelongs to the SEC23/SEC24 family. SEC23 subfamily.
Cellular localizationSmooth endoplasmic reticulum membrane. Golgi apparatus membrane. In the ribosome-free transitional face of the ER and associated vesicles.
- Information by UniProt
ab4960 has not yet been referenced specifically in any publications.