• Product name

  • Description

    Rabbit polyclonal to SEC23B
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-210 of Human SEC23B (Uniprot: Q15437).

  • Positive control

    • Raji whole cell lysate, Ca922 oral cancer xenograft



Our Abpromise guarantee covers the use of ab151258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 86 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternatively Tris-EDTA buffer ( pH8.0) may be used.


  • Function

    Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
  • Involvement in disease

    Defects in SEC23B are the cause of congenital dyserythropoietic anemia type 2 (CDA2) [MIM:224100]. An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, normocytic anemia, iron overload, jaundice, and variable splenomegaly. Ultrastructural features include bi- or multinucleated erythroblasts in bone marrow, karyorrhexis, and the presence of Gaucher-like bone marrow histiocytes. The main biochemical feature of the disease is defective glycosylation of some red blood cells membrane proteins.
  • Sequence similarities

    Belongs to the SEC23/SEC24 family. SEC23 subfamily.
  • Cellular localization

    Golgi apparatus membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CDA II antibody
    • CDAII antibody
    • CDAN2 antibody
    • HEMPAS antibody
    • Protein transport protein Sec23B antibody
    • RP11-379J5.1 antibody
    • SC23B_HUMAN antibody
    • Sec23 homolog B (S. cerevisiae) antibody
    • SEC23 related protein B antibody
    • SEC23-like protein B antibody
    • SEC23-related protein B antibody
    • Sec23b antibody
    • Transport protein SEC23B antibody
    see all


  • Anti-SEC23B antibody (ab151258) at 1/1000 dilution + Raji whole cell
    lysate at 30 µg

    Predicted band size: 86 kDa

    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin embedded Human Ca922 oral cancer xenograft labeling SEC23B with ab151258 antibody at 1/500.


This product has been referenced in:

  • Yehia L  et al. Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway. Hum Mol Genet 27:3154-3164 (2018). Read more (PubMed: 29893852) »
  • Yehia L  et al. Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. Am J Hum Genet 97:661-76 (2015). Read more (PubMed: 26522472) »
See all 2 Publications for this product

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