Anti-SECISBP2 antibody [2957C2a] (ab70601)
Key features and details
- Mouse monoclonal [2957C2a] to SECISBP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-SECISBP2 antibody [2957C2a]
See all SECISBP2 primary antibodies -
Description
Mouse monoclonal [2957C2a] to SECISBP2 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment of human SECISBP2 derived from a near N terminal internal sequence.
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Positive control
- HEK293 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 1% BSA, 0.03% Potassium phosphate, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.0225% Potassium chloride, 0.0204% Monobasic dihydrogen potassium phosphate, 0.1136% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab70601 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane. -
Clonality
Monoclonal -
Clone number
2957C2a -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab70601 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.2 - 2 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 95 kDa).
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Notes |
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WB
Use a concentration of 0.2 - 2 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 95 kDa). |
Target
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Function
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. -
Tissue specificity
Expressed at high levels in testis. -
Involvement in disease
Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 79048 Human
- Omim: 607693 Human
- SwissProt: Q96T21 Human
- Unigene: 59804 Human
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Alternative names
- DKFZp686C09169 antibody
- OTTHUMP00000064929 antibody
- OTTHUMP00000064930 antibody
see all
Images
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Anti-SECISBP2 antibody [2957C2a] (ab70601) at 2 µg/ml + HEK293 whole cell lysate at 25 µg
Developed using the ECL technique.
Predicted band size: 95 kDa
Observed band size: 105 kDa why is the actual band size different from the predicted?
Datasheets and documents
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Datasheet download
References (0)
ab70601 has not yet been referenced specifically in any publications.