Anti-SECISBP2 antibody (ab210791)
Key features and details
- Rabbit polyclonal to SECISBP2
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-SECISBP2 antibody
See all SECISBP2 primary antibodies -
Description
Rabbit polyclonal to SECISBP2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant fragment corresponding to Human SECISBP2 aa 270-854 (C terminal).
Database link: Q96T21 -
Positive control
- IF; HeLa cells. WB: MCF7, BT-474, HeLa, 293T and mouse thymus extract. IHC-P: Human liver injury tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab210791 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200.
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WB |
1/500 - 1/2000. Predicted molecular weight: 95 kDa.
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IF |
1/50 - 1/100.
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Notes |
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IHC-P
1/50 - 1/200. |
WB
1/500 - 1/2000. Predicted molecular weight: 95 kDa. |
IF
1/50 - 1/100. |
Target
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Function
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. -
Tissue specificity
Expressed at high levels in testis. -
Involvement in disease
Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 79048 Human
- Entrez Gene: 75420 Mouse
- Omim: 607693 Human
- SwissProt: Q96T21 Human
- Unigene: 59804 Human
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Alternative names
- DKFZp686C09169 antibody
- OTTHUMP00000064929 antibody
- OTTHUMP00000064930 antibody
see all
Images
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All lanes : Anti-SECISBP2 antibody (ab210791) at 1/500 dilution
Lane 1 : MCF7 extract
Lane 2 : BT-474 extract
Lane 3 : HeLa extract
Lane 4 : 293T extract
Lane 5 : Mouse thymus
Predicted band size: 95 kDa -
Immunohistochemical analysis of human colon carcinoma tissue paraffin-embedded sections labeling SECISBP2 with ab210791 at a 1/200 dilution.
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Immunofluorescent analysis of HeLa cells labeling SECISBP2 with ab210791 at 1/50 dilution.
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Immunohistochemical analysis of human liver injury tissue paraffin-embedded sections labeling SECISBP2 with ab210791 at a 1/200 dilution.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab210791 has not yet been referenced specifically in any publications.