Anti-SEMA6D antibody - N-terminal (ab198745)
Key features and details
- Rabbit polyclonal to SEMA6D - N-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SEMA6D antibody - N-terminal -
Description
Rabbit polyclonal to SEMA6D - N-terminal -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human SEMA6D (N terminal). The exact sequence is proprietary. From isoform 8 (NP_705872).
Database link: Q8NFY4-8 -
Positive control
- paraffin-embedded Human liver cancer tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198745 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/25 - 1/100.
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Notes |
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IHC-P
1/25 - 1/100. |
Target
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Relevance
SEMA6D belongs to the semaphorin family of proteins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. SEMA6D shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro and may be a stop signal for DRG neurons in their target areas, and possibly also for other neurons. It may also be involved in the maintenance and remodeling of neuronal connections. -
Cellular localization
Isoforms 1-6: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cytoplasm. -
Database links
- Entrez Gene: 80031 Human
- Omim: 609295 Human
- SwissProt: Q8NFY4 Human
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Alternative names
- KIAA1479 antibody
- Q8NFY4 antibody
- Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D antibody
- Semaphorin 6D antibody
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab198745 has been referenced in 1 publication.
- Baxter DE et al. MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer. Cancers (Basel) 13:N/A (2021). PubMed: 34885090