Key features and details
- Rat monoclonal [MM0537-99D22] to Semaphorin 7a
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2
Product nameAnti-Semaphorin 7a antibody [MM0537-99D22]
See all Semaphorin 7a primary antibodies
DescriptionRat monoclonal [MM0537-99D22] to Semaphorin 7a
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment: , corresponding to amino acids 46-645 of Human Semaphorin 7a
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein G purified
Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter.
Our Abpromise guarantee covers the use of ab90242 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionPlays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Tissue specificityDetected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Sequence similaritiesBelongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.
Cellular localizationCell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
- Information by UniProt
- CD 108 antibody
- CD108 antibody
- CD108 antigen antibody
ab90242 has not yet been referenced specifically in any publications.