Product nameSemaphorin 7a peptide
See all Semaphorin 7a proteins and peptides
Our Abpromise guarantee covers the use of ab176249 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Semaphorin 7a antibody (ab133803)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
- CD 108
- CD108 antigen
FunctionPlays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Tissue specificityDetected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Sequence similaritiesBelongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.
Cellular localizationCell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
- Information by UniProt
ab176249 has not yet been referenced specifically in any publications.