Overview

  • Product name

    Sennoside B, PDGF inhibitor
  • Description

    PDGF inhibitor
  • Biological description

    Platelet-derived Growth Factor (PDGF) inhibitor. Sennoside A (ab145726) analog. Inhibits PDGF-induced proliferation. Shows laxative effects in vivo. Orally active.
  • CAS Number

    128-57-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (9S)-9-[(9R)-2-Carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
  • Molecular weight

    862.74
  • Molecular formula

    C42H38O20
  • PubChem identifier

    91440
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C([C@@H]2[C@H]5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chen YC  et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci 84:915-22 (2009). Read more (PubMed: 19393247) »
  • Takizawa Y  et al. Pharmacokinetics of rhein from Onpi-to, an Oriental herbal medicine, in rats. Biol Pharm Bull 26:613-7 (2003). Read more (PubMed: 12736499) »
  • Morinaga O  et al. Production of monoclonal antibodies against a major purgative component, sennoside B, their characterization and use in ELISA. Analyst 126:1372-6 (2001). Read more (PubMed: 11534608) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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