Overview

  • Product name

  • Description

    Rabbit polyclonal to SEPSECS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SEPSECS aa 5-451.
    Database link: Q9HD40

  • Positive control

    • WB: HEK-293T whole cell lysate. IHC-P: Human kidney tissue. ICC/IF: PC-3 cells.
  • General notes

    Previously labelled as Soluble Liver/Pancreas Antigen.

Properties

Applications

Our Abpromise guarantee covers the use of ab236956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/500 - 1/2000.
ICC/IF 1/50 - 1/200.

Target

  • Function

    Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
  • Tissue specificity

    Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
  • Pathway

    Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.
  • Involvement in disease

    Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D) [MIM:613811]. PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures.
  • Sequence similarities

    Belongs to the SepSecS family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp434B1417 antibody
    • Liver pancreas antigen antibody
    • Liver-pancreas antigen antibody
    • LP antibody
    • MGC161491 antibody
    • O phosphoseryl tRNA(Sec) selenium transferase antibody
    • O-phosphoseryl-tRNA(Sec) selenium transferase antibody
    • Sec synthase antibody
    • Selenocysteine synthase antibody
    • Selenocysteinyl tRNA(Sec) synthase antibody
    • Selenocysteinyl-tRNA(Sec) synthase antibody
    • Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase antibody
    • Sep tRNA:Sec tRNA synthase antibody
    • Sep-tRNA:Sec-tRNA synthase antibody
    • SepSecS antibody
    • SLA antibody
    • SLA p35 antibody
    • SLA-p35 antibody
    • SLA/LP antibody
    • SLA/LP autoantigen antibody
    • Soluble liver antigen antibody
    • Soluble liver antigen/liver pancreas antigen antibody
    • Soluble Liver/Pancreas Antigen antibody
    • SPCS_HUMAN antibody
    • tRNA(Ser/Sec) associated antigenic protein antibody
    • tRNA(Ser/Sec)-associated antigenic protein antibody
    • TRNP48 antibody
    • UGA suppressor tRNA associated protein antibody
    • UGA suppressor tRNA-associated protein antibody
    see all

Images

  • Anti-SEPSECS antibody (ab236956) at 1/500 dilution + HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

    Secondary
    Goat polyclonal to Rabbit IgG at 1/10000 dilution
  • Paraffin-embedded human kidney tissue stained for SEPSECS with ab236956 at a 1/100 dilution in immunohistochemical analysis.

  • PC-3 (Human prostate adenocarcinoma cell line) cells stained for SEPSECS (Green) using ab236956 at a 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

References

ab236956 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab236956.
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