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    sept4-antibody-ab9651.pdf

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Cell Biology Cell Cycle Cell Division Cytokinesis
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Anti-SEPT4 antibody (ab9651)

  • Datasheet
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Western blot - Anti-SEPT4 antibody (ab9651)

    Key features and details

    • Rabbit polyclonal to SEPT4
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human SEPT4 protein (ab131801)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-SEPT4 antibody
      See all SEPT4 primary antibodies
    • Description

      Rabbit polyclonal to SEPT4
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human SEPT4 aa 3-14.
      Sequence:

      KRFLEDTTDDGE


      (Peptide available as ab9652)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Human lung, kidney and spleen tissue lysates.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      pH: 7.2
      Preservative: 0.02% Sodium azide
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cell Biology
      • Cell Cycle
      • Cell Division
      • Cytokinesis
      • Signal Transduction
      • Second Messenger
      • Nucleotide Messenger
      • GTP
      • Cell Biology
      • Apoptosis
      • Mitochondrial
      • Cell Biology
      • Cell Cycle
      • Cell Division
      • Other cell division antibodies
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Mitochondrial markers
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Apoptosis
      • Cancer
      • Cell Death
      • Apoptosis
      • Mitochondrial
      • Cancer
      • Cell Death
      • Apoptosis
      • Metabolism

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human SEPT4 protein (ab131801)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab9651 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    Application Abreviews Notes
    WB
    Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 32 kDa.
    Notes
    WB
    Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 32 kDa.

    Target

    • Function

      Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
    • Tissue specificity

      Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets.
    • Sequence similarities

      Belongs to the septin family.
    • Cellular localization

      Cytoplasm. Cytoplasm > cytoskeleton. In platelets, found in areas surrounding alpha-granules and Mitochondrion. Nucleus. While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.
    • Target information above from: UniProt accession O43236 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 5414 Human
      • Omim: 603696 Human
      • SwissProt: O43236 Human
      • Unigene: 287518 Human
      • Alternative names

        • Apoptosis-related protein in the TGF-beta signaling pathway antibody
        • ARTS antibody
        • Bradeion antibody
        • Bradeion beta antibody
        • Brain protein H5 antibody
        • CE5B3 antibody
        • CE5B3 beta antibody
        • Cell division control-related protein 2 antibody
        • Cerebral protein 7 antibody
        • H5 antibody
        • hCDCREL-2 antibody
        • hucep-7 antibody
        • MART antibody
        • Peanut-like protein 2 antibody
        • PNUTL2 antibody
        • SEP 4 antibody
        • SEP4 antibody
        • Sept4 antibody
        • SEPT4_HUMAN antibody
        • Septin M antibody
        • Septin-4 antibody
        see all

      Images

      • Western blot - Anti-SEPT4 antibody (ab9651)
        Western blot - Anti-SEPT4 antibody (ab9651)

        Western blot analysis of SEPT4 expression in human lung (lane 1), spleen (lane 2), and kidney (lane 3) tissue lysates with anti-SEPT4 at 2 µg /ml.

        Western blot analysis of SEPT4 expression in human lung (lane 1), spleen (lane 2), and kidney (lane 3) tissue lysates with anti-SEPT4 at 2 µg /ml.

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab9651? Please let us know so that we can cite the reference in this datasheet.

      ab9651 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Show All Reviews Q&A
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      Immunoprecipitation abreview for Anti-SEPT4 antibody

      Poor
      Abreviews
      Abreviews
      abreview image
      Application
      Immunoprecipitation
      Sample
      Human Cell lysate - whole cell (PC3 cells (prostate))
      Total protein in input
      3e+006 cells
      Immuno-precipitation step
      Protein A/G
      Specification
      PC3 cells (prostate)
      Read More

      Abcam user community

      Verified customer

      Submitted Oct 23 2018

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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