Serabelisib, phosphoinositide 3-kinase alpha inhibitor (ab235549)

Overview

  • Product name

    Serabelisib, phosphoinositide 3-kinase alpha inhibitor
  • Description

    Potent, selective phosphoinositide 3-kinase α inhibitor
  • Alternative names

    • INK-1117
    • INK1117
    • MLN-1117
    • MLN1117
    • TAK-117
    see all
  • Biological description

    Potent, selective phosphoinositide 3-kinase α (PI3Kα) inhibitor (IC50 =15nM for PI3Kα vs. >1 µM for other isoforms in vitro). 100-fold selectivity relative to other class I PI3K family members and mTOR as well as a high degree of selectivity against a large panel of protein kinases. Orally bioavailable.

  • Purity

    > 98%
  • CAS Number

    1268454-23-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone

  • Molecular weight

    363.34
  • Molecular formula

    C19H17N5O3
  • PubChem identifier

    70798655
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 44.03 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1COCCN1C(=O)C2=CN=C3N2C=C(C=C3)C4=CC5=C(C=C4)OC(=N5)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Yea SS  et al. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One 9:e99486 (2014). Read more (PubMed: 24915189) »
  • So L  et al. Selective inhibition of phosphoinositide 3-kinase p110a preserves lymphocyte function. J Biol Chem 288:5718-31 (2013). Read more (PubMed: 23275335) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab235549.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up