Product nameSerabelisib, phosphoinositide 3-kinase alpha inhibitor
DescriptionPotent, selective phosphoinositide 3-kinase α inhibitor
Potent, selective phosphoinositide 3-kinase α (PI3Kα) inhibitor (IC50 =15nM for PI3Kα vs. >1 µM for other isoforms in vitro). 100-fold selectivity relative to other class I PI3K family members and mTOR as well as a high degree of selectivity against a large panel of protein kinases. Orally bioavailable.
Storage instructionsShipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
Soluble in DMSO to 44.03 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Yea SS et al. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One 9:e99486 (2014). Read more (PubMed: 24915189) »
- So L et al. Selective inhibition of phosphoinositide 3-kinase p110a preserves lymphocyte function. J Biol Chem 288:5718-31 (2013). Read more (PubMed: 23275335) »