Key features and details
- Rabbit polyclonal to Serotonin
- Suitable for: ELISA, ICC
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-Serotonin antibody
See all Serotonin primary antibodies
DescriptionRabbit polyclonal to Serotonin
Tested applicationsSuitable for: ELISA, ICCmore details
Species reactivityReacts with: Species independent
Chemical/ Small Molecule corresponding to Serotonin. Synthetic 5-Hydroxytryptamine conjugated to protein carrier (PC)
ab6444 specific to conjugated 5-Hydroxytryptamine (Serotonin)
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration information loading...
PurityAmmonium Sulphate Precipitation
Our Abpromise guarantee covers the use of ab6444 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent concentration.|
|ICC||Use at an assay dependent concentration.|
RelevanceSerotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.
Cellular localizationCytoplasmic and Secreted
- 5 hydroxytryptamine antibody
- 5HT antibody
ab6444 has been referenced in 1 publication.
- Chen Y et al. Stress inhibits tryptophan hydroxylase expression in a rat model of depression. Oncotarget 8:63247-63257 (2017). PubMed: 28968985