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Rabbit polyclonal to Serotonin N-acetyltransferase
Predicted to work with:
Synthetic peptide within Human Serotonin N-acetyltransferase aa 170-205 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
R FSFHAVGPCA ITVGSLTFME LHCSLRGHPF
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Preservative: 0.09% Sodium azide
Constituents: 1% BSA, 50% Glycerol
Concentration information loading...
Protein A purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
When using a fluorescent probe the recommended dilution is 1/50 – 1/200.
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Involvement in disease
Delayed sleep phase syndrome
Belongs to the acetyltransferase family. AANAT subfamily.
Contains 1 N-acetyltransferase domain.
cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
Information by UniProt
Aralkylamine N-acetyltransferase antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serotonin N-acetyltransferase antibody (ab203190)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain tissue labeling Serotonin N-acetyltransferase with ab203190 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
has not yet been referenced specifically in any publications.
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