Overview

  • Product name

    Anti-Serotonin transporter (phospho T276) antibody
    See all Serotonin transporter primary antibodies
  • Description

    Rabbit polyclonal to Serotonin transporter (phospho T276)
  • Host species

    Rabbit
  • Specificity

    ab194262 is specific for Serotonin transporter phosphorylated at Thr276. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Sheep, Cow, Human, Non human primates
  • Immunogen

    Synthetic peptide corresponding to Rat Serotonin transporter (phospho T276).
    Database link: P31652

  • Positive control

    • Rat mid brain membrane lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab194262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 70 kDa.

Target

  • Function

    Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
  • Tissue specificity

    Expressed in platelets (at protein level).
  • Sequence similarities

    Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
  • Post-translational
    modifications

    Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.
    Phosphorylated at Ser-611, Thr-613 and Thr-616.
  • Cellular localization

    Cell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5 HTT antibody
    • 5 HTTLPR antibody
    • 5 hydroxytryptamine (serotonin) transporter antibody
    • 5 hydroxytryptamine transporter antibody
    • 5HT transporter antibody
    • 5HTT antibody
    • hSERT antibody
    • HTT antibody
    • Na+/Cl- dependent serotonin transporter antibody
    • OCD1 antibody
    • SC6A4_HUMAN antibody
    • Serotonin transporter 1 antibody
    • SERT antibody
    • SERT1 antibody
    • Slc6a4 antibody
    • Sodium dependent serotonin transporter antibody
    • Sodium-dependent serotonin transporter antibody
    • Solute carrier family 6 (neurotransmitter transporter) member 4 antibody
    • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody
    • Solute carrier family 6 member 4 antibody
    see all

Images

  • All lanes : Anti-Serotonin transporter (phospho T276) antibody (ab194262) at 1/1000 dilution

    Lane 1 : Rat mid brain membrane lysate
    Lane 2 : Rat mid brain membrane lysate with immunizing peptide

    Predicted band size: 70 kDa

References

ab194262 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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