Overview

  • Product name

    Anti-SerpinB6/CAP antibody
    See all SerpinB6/CAP primary antibodies
  • Description

    Rabbit polyclonal to SerpinB6/CAP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human SerpinB6/CAP aa 250-300. The exact sequence is proprietary.
    Database link: P35237

  • Positive control

    • IP: HeLa whole cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab240611 was affinity purified using an epitope specific to SerpinB6/CAP immobilized on solid support.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab240611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function

      May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
    • Tissue specificity

      Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
    • Involvement in disease

      Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
    • Sequence similarities

      Belongs to the serpin family. Ov-serpin subfamily.
    • Cellular localization

      Cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • CAP antibody
      • Cytoplasmic antiproteinase antibody
      • Peptidase inhibitor 6 antibody
      • PI-6 antibody
      • PI6 antibody
      • Placental thrombin inhibitor antibody
      • Protease inhibitor 6 (placental thrombin inhibitor) antibody
      • PTI antibody
      • Serpin B6 antibody
      • SERPINB6 antibody
      • SPB6_HUMAN antibody
      see all

    Images

    • SerpinB6/CAP was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab240611 at 6 µg/mg lysate. Western blot was performed from the immunoprecipitate using ab240611 at 0.4 µg/ml.

      Lane 1: ab240611 IP in HeLa whole cell lysate.

      Lane 2: Control IgG IP in HeLa whole cell lysate.

      Detection:  Chemiluminescence with exposure time of 30 seconds.

    References

    ab240611 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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