Key features and details
- Rabbit polyclonal to SerpinB6/CAP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SerpinB6/CAP antibody
See all SerpinB6/CAP primary antibodies
DescriptionRabbit polyclonal to SerpinB6/CAP
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human SerpinB6/CAP aa 66-283.
- A549 and HeLa whole cell lysates; HepG2 and HCT116 cell lysates
Product previously known as Anti-SerpinB6 antibody.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97330 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 42 kDa.|
FunctionMay be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Tissue specificityExpressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
Involvement in diseaseDefects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
Sequence similaritiesBelongs to the serpin family. Ov-serpin subfamily.
- Information by UniProt
- CAP antibody
- Cytoplasmic antiproteinase antibody
- Peptidase inhibitor 6 antibody
ab97330 has been referenced in 1 publication.
- Ben-Lulu S et al. Nitrosothiol-Trapping-Based Proteomic Analysis of S-Nitrosylation in Human Lung Carcinoma Cells. PLoS One 12:e0169862 (2017). PubMed: 28081246