Overview

  • Product name
    Anti-SERPINE2 / PN-1 antibody
    See all SERPINE2 / PN-1 primary antibodies
  • Description
    Rabbit polyclonal to SERPINE2 / PN-1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human SERPINE2/ PN-1 aa 163-385.
    Database link: P07093

  • Positive control
    • HeLa, HepG2 and Mouse brain whole cell lysates; HeLa cells; Human gastric carcinoma tissue.
  • General notes

    Previously labelled as SERPINE2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab154591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
  • Sequence similarities
    Belongs to the serpin family.
  • Cellular localization
    Secreted > extracellular space.
  • Information by UniProt
  • Database links
  • Alternative names
    • GDN antibody
    • GDN_HUMAN antibody
    • GDNPF antibody
    • Glia derived nexin antibody
    • Glia-derived nexin antibody
    • Glial derived neurite promoting factor antibody
    • P17 antibody
    • Peptidase inhibitor 7 antibody
    • Pi-7 antibody
    • Plasminogen activator inhibitor type 1, member 2 antibody
    • PN-1 antibody
    • PN1 antibody
    • PNI antibody
    • Protease inhibitor 7 antibody
    • Protease nexin 1 antibody
    • Protease nexin I antibody
    • Serpin E2 antibody
    • Serpin family E member 2 antibody
    • Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 antibody
    • SERPINE 2 antibody
    • Serpine2 antibody
    see all

Images

  • All lanes : Anti-SERPINE2 / PN-1 antibody (ab154591) at 1/2000 dilution

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 44 kDa



    10% SDS PAGE
  • Anti-SERPINE2 / PN-1 antibody (ab154591) at 1/2000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 44 kDa



    10% SDS PAGE
  • Immunofluorescence analysis of methanol-fixed HeLa cells labeling SERPINE2 / PN-1 with ab154591 at 1/500 dilution. Lower image shows cells co-stained with Hoechst 33342.

  • Immunohistochemical analysis of paraffin-embedded Human Gastric carcinoma tissue labeling SERPINE2 / PN-1 with ab154591 at 1/500 dilution.

References

This product has been referenced in:
  • Li YB  et al. miR-199a-3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2. Mol Med Rep 16:2417-2424 (2017). Read more (PubMed: 28677735) »
  • Wu X  et al. The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration. Sci Rep 6:30563 (2016). Read more (PubMed: 27460424) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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