Overview

  • Product name

  • Description

    Rabbit polyclonal to SERPING1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human SERPING1 aa 201-500 (C terminal).
    Sequence:

    KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV LWDQQHKFPV FMGRVYDPRA


    Database link: P05155

  • Positive control

    • HL60, DU145, SW480, MCF7, HeLa and HepG2 whole cell lysate (ab7900).
  • General notes

     This product was previously labelled as C1 Inactivator

     

Properties

Applications

Our Abpromise guarantee covers the use of ab180774 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 55 kDa.
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function

    Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • Involvement in disease

    Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • Sequence similarities

    Belongs to the serpin family.
  • Post-translational
    modifications

    Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C1 esterase inhibitor antibody
    • C1 Inh antibody
    • C1 inhibiting factor antibody
    • C1 inhibitor antibody
    • C1-inhibiting factor antibody
    • C1IN antibody
    • C1Inh antibody
    • C1NH antibody
    • complement component 1 inhibitor antibody
    • esterase inhibitor antibody
    • HAE1 antibody
    • HAE2 antibody
    • IC1_HUMAN antibody
    • Plasma protease C1 inhibitor antibody
    • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
    • serine/cysteine proteinase inhibitor clade G member 1 antibody
    • Serpin G1 antibody
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
    • SERPING1 antibody
    see all

Images

  • All lanes : Anti-SERPING1 antibody (ab180774) at 1/500 dilution

    Lane 1 : HL60 cell lysate
    Lane 2 : DU145 cell lysate
    Lane 3 : SW480 cell lysate
    Lane 4 : MCF7 cell lysate
    Lane 5 : HeLa cell lysate
    Lane 6 : HepG2 cell lysate

    Predicted band size: 55 kDa

References

ab180774 has not yet been referenced specifically in any publications.

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