Overview

  • Product name

  • Description

    Rabbit polyclonal to SERPING1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment within Human SERPING1 (internal sequence). The exact sequence is proprietary.
    Database link: P05155

  • Positive control

    • WB: Human, mouse and rat plasma. IHC-P: Human hepatoma tissue.
  • General notes

     This product was previously labelled as C1 Inactivator

     

Properties

Applications

Our Abpromise guarantee covers the use of ab229209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/10000. Predicted molecular weight: 55 kDa.

Target

  • Function

    Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • Involvement in disease

    Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • Sequence similarities

    Belongs to the serpin family.
  • Post-translational
    modifications

    Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C1 esterase inhibitor antibody
    • C1 Inh antibody
    • C1 inhibiting factor antibody
    • C1 inhibitor antibody
    • C1-inhibiting factor antibody
    • C1IN antibody
    • C1Inh antibody
    • C1NH antibody
    • complement component 1 inhibitor antibody
    • esterase inhibitor antibody
    • HAE1 antibody
    • HAE2 antibody
    • IC1_HUMAN antibody
    • Plasma protease C1 inhibitor antibody
    • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
    • serine/cysteine proteinase inhibitor clade G member 1 antibody
    • Serpin G1 antibody
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
    • SERPING1 antibody
    see all

Images

  • Anti-SERPING1 antibody (ab229209) at 1/5000 dilution + Human plasma at 30 µg

    Predicted band size: 55 kDa



    7.5% SDS-PAGE gel.

  • Paraffin-embedded human hepatoma tissue stained for SERPING1 using ab229209 at 1/500 dilution in immunohistochemical analysis.

  • Anti-SERPING1 antibody (ab229209) at 1/1000 dilution + Mouse plasma at 50 µg

    Predicted band size: 55 kDa



    10% SDS-PAGE gel.

  • Anti-SERPING1 antibody (ab229209) at 1/1000 dilution + Rat plasma at 50 µg

    Predicted band size: 55 kDa



    10% SDS-PAGE gel.

References

ab229209 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab229209.
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