Overview

  • Product name

    Anti-Serum Amyloid A antibody [5G6]
  • Description

    Mouse monoclonal [5G6] to Serum Amyloid A
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human Serum Amyloid A.
    Database link: P0DJI8

  • Positive control

    • IHC-P: Human liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab230912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.
  • Cellular localization

    Secreted
  • Database links

  • Alternative names

    • Amyloid fibril protein AA antibody
    • Amyloid protein A antibody
    • MGC111216 antibody
    • OTTMUSP00000045357 antibody
    • PIG4 antibody
    • SAA antibody
    • SAA1 antibody
    • SAA2 antibody
    • Serum amyloid A 1 antibody
    • Serum amyloid A 1 protein antibody
    • serum amyloid A protein antibody
    • Serum amyloid A protein precursor antibody
    • Serum amyloid A1 isoform 1 antibody
    • Serum amyloid A1 isoform 2 antibody
    • TP53I4 antibody
    • Tumor protein p53 inducible protein 4 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human liver tissue stained for Serum Amyloid A using ab230912 at 1/50 dilution in immunohistochemical analysis.

References

ab230912 has not yet been referenced specifically in any publications.

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