Anti-Serum Amyloid A antibody [Reu-86.2] (ab8057)
Key features and details
- Mouse monoclonal [Reu-86.2] to Serum Amyloid A
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-Serum Amyloid A antibody [Reu-86.2]
See all Serum Amyloid A primary antibodies -
Description
Mouse monoclonal [Reu-86.2] to Serum Amyloid A -
Host species
Mouse -
Specificity
The antibody reacts with AA-type Amyloid depositions. -
Species reactivity
Reacts with: Human -
Immunogen
Human serum Amyloid A (Apo-SAA).
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Positive control
- Amyloid depositions (renal biopsy).
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General notes
Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.3 -
Concentration information loading... -
Purity
Tissue culture supernatant -
Primary antibody notes
Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type. -
Clonality
Monoclonal -
Clone number
Reu-86.2 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Relevance
Function: Major acute phase reactant. Apolipoprotein of the HDL complex. Tissue specificity: Expressed by the liver; secreted in plasma. Disease: Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Note=Elevated serum SAA protein levels may be associated with lung cancer. Similarity: Belongs to the SAA family. PTM: This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end. -
Database links
- Entrez Gene: 694827 Human
- Omim: 104750 Human
- SwissProt: P0DJI8 Human
- SwissProt: P0DJI9 Human
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Alternative names
- Amyloid fibrils antibody
- SAA 2 antibody
- Serum amyloid A1 isoform 2 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab8057 has been referenced in 1 publication.
- Hazenberg BPC (Natvig JB Eds.) et al. Detection of Amyloid AA in rectal biopsies with a new monoclonal anti-human SAA antibody (Reu 86.2). Amyloid and Amyloidosis :809-812 (1991). PubMed: