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    serum-amyloid-a-antibody-reu-862-ab8057.pdf

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Cardiovascular Blood Acute Phase Reactants
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Anti-Serum Amyloid A antibody [Reu-86.2] (ab8057)

  • Datasheet
  • SDS
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Key features and details

  • Mouse monoclonal [Reu-86.2] to Serum Amyloid A
  • Reacts with: Human
  • Isotype: IgG2a

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Goat Anti-Mouse IgG H&L (HRP) (ab205719)
Protein
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Recombinant human Serum Amyloid A protein (ab50232)

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Overview

  • Product name

    Anti-Serum Amyloid A antibody [Reu-86.2]
    See all Serum Amyloid A primary antibodies
  • Description

    Mouse monoclonal [Reu-86.2] to Serum Amyloid A
  • Host species

    Mouse
  • Specificity

    The antibody reacts with AA-type Amyloid depositions.
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Human serum Amyloid A (Apo-SAA).

  • Positive control

    • Amyloid depositions (renal biopsy).
  • General notes


    Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Primary antibody notes

    Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.
  • Clonality

    Monoclonal
  • Clone number

    Reu-86.2
  • Isotype

    IgG2a
  • Research areas

    • Cardiovascular
    • Blood
    • Acute Phase Reactants
    • Cardiovascular
    • Blood
    • Serum Proteins
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipoproteins/Apolipoproteins
    • Lipoproteins

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)
  • Recombinant Protein

    • Recombinant human Serum Amyloid A protein (ab50232)

Target

  • Relevance

    Function: Major acute phase reactant. Apolipoprotein of the HDL complex. Tissue specificity: Expressed by the liver; secreted in plasma. Disease: Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Note=Elevated serum SAA protein levels may be associated with lung cancer. Similarity: Belongs to the SAA family. PTM: This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
  • Database links

    • Entrez Gene: 694827 Human
    • Omim: 104750 Human
    • SwissProt: P0DJI8 Human
    • SwissProt: P0DJI9 Human
    • Alternative names

      • Amyloid fibrils antibody
      • SAA 2 antibody
      • Serum amyloid A1 isoform 2 antibody
      • TP53I4 antibody
      • Amyloid fibril protein AA antibody
      • Amyloid protein A antibody
      • Fibrils antibody
      • MGC111216 antibody
      • OC antibody
      • OTTMUSP0000004557 antibody
      • PIG 4 antibody
      • PIG4 antibody
      • SAA 1 antibody
      • SAA antibody
      • SAA_HUMAN antibody
      • SAA1 antibody
      • SAA2 antibody
      • Serum amyloid A 1 antibody
      • serum amyloid A antibody
      • Serum amyloid A protein precursor antibody
      • Serum amyloid A1 isoform 1 antibody
      • Serum amyloid protein A(4-101) antibody
      • Tumor protein p53 inducible protein 4 antibody
      see all

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab8057? Please let us know so that we can cite the reference in this datasheet.

    ab8057 has been referenced in 1 publication.

    • Hazenberg BPC (Natvig JB Eds.) et al. Detection of Amyloid AA in rectal biopsies with a new monoclonal anti-human SAA antibody (Reu 86.2). Amyloid and Amyloidosis :809-812 (1991). PubMed:

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