Anti-Serum Amyloid A antibody [Reu-86.2] (ab8057)
- Datasheet
- References (1)
- Protocols
Overview
-
Product nameAnti-Serum Amyloid A antibody [Reu-86.2]
See all Serum Amyloid A primary antibodies -
DescriptionMouse monoclonal [Reu-86.2] to Serum Amyloid A
-
Host speciesMouse
-
SpecificityThe antibody reacts with AA-type Amyloid depositions.
-
Tested applicationsSuitable for: IHC-Fr, IHC-Pmore details
-
Species reactivityReacts with: Human
-
Immunogen
Human serum Amyloid A (Apo-SAA).
-
Positive control
- Amyloid depositions (renal biopsy).
-
General notes
Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.
Properties
-
FormLiquid
-
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
-
PurityTissue culture supernatant
-
Primary antibody notesAmyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.
-
ClonalityMonoclonal
-
Clone numberReu-86.2
-
IsotypeIgG2a
-
Research areas
Associated products
-
Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab8057 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-Fr | Use at an assay dependent concentration. | |
| IHC-P | Use at an assay dependent concentration. |
Target
-
FunctionMajor acute phase reactant. Apolipoprotein of the HDL complex.
-
Tissue specificityExpressed by the liver; secreted in plasma.
-
Involvement in diseaseNote=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Note=Elevated serum SSA protein levels may be associated with lung cancer. -
Sequence similaritiesBelongs to the SAA family.
-
Post-translational
modificationsThis protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end. -
Cellular localizationSecreted.
- Information by UniProt
-
Database links
- Entrez Gene: 6288 Human
- Entrez Gene: 6289 Human
- Entrez Gene: 694827 Human
- Omim: 104750 Human
- SwissProt: P02735 Human
- SwissProt: P0DJI8 Human
- Unigene: 1955 Human
- Unigene: 632144 Human
-
Alternative names
- Amyloid fibril protein AA antibody
- Amyloid fibrils antibody
- Amyloid protein A antibody
see all
Datasheets and documents
Protocols
References
This product has been referenced in:
- Hazenberg BPC (Natvig JB Eds.) et al. Detection of Amyloid AA in rectal biopsies with a new monoclonal anti-human SAA antibody (Reu 86.2). Amyloid and Amyloidosis :809-812 (1991). Read more (PubMed: ) »
