Overview

  • Product name

    Sesamin (Fagarol), chemopreventive agent
  • Description

    Chemopreventive agent
  • Biological description

    Chemopreventive agent. Potentiates antioxidant enzymes. Upregulates the expression of SOD. Inhibits the conversion of DGLA to arachidonic acid (Ki = 155 μM). Non-competitive desaturase inhibitor. Antioxidant, neuroprotective, hepatoprotective and antiaging effects in vivo.
  • Purity

    > 99%
  • CAS Number

    607-80-7
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    354.35
  • Molecular formula

    C20H18O6
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C12=C(C=CC(=C1)[C@H]3OC[C@]4([C@]3(CO[C@@H]4C5=CC6=C(C=C5)OCO6)[H])[H])OCO2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ma JQ  et al. Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway. Food Chem Toxicol 64:41-8 (2014). Read more (PubMed: 24287204) »
  • Pothacharoen P  et al. Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture. Glycoconj J : (2013). Read more (PubMed: 24338203) »
  • Zuo Y  et al. Sesamin extends the mean lifespan of fruit flies. Biogerontology 14:107-19 (2013). Read more (PubMed: 23291977) »

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