Overview

  • Product name

    SF1670, PTEN inhibitor
  • Description

    Selective PTEN inhibitor
  • Alternative names

    • PTP Inhibitor XIX
  • Biological description

    Selective PTEN inhibitor (IC50 = 2 μM). Elevates intracellular PIP3 signaling. Reduces neutrophil functions, including phagocytosis, oxidative burst, polarization, and chemotaxis. Active in vivo.

  • Purity

    > 98%
  • CAS Number

    345630-40-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(9,10-Dioxophenanthren-2-yl)-2,2-dimethylpropanamide
  • Molecular weight

    307.35
  • Molecular formula

    C19H17NO3
  • PubChem identifier

    9926586
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)C(=O)Nc1ccc2c(c1)C(=O)C(=O)c3ccccc23
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li Y  et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117:6702-13 (2011). Read more (PubMed: 21521784) »
See 1 Publication for this product

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