SF1670, PTEN inhibitor (ab141303)
Key features and details
- Selective PTEN inhibitor
- CAS Number: 345630-40-2
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
SF1670, PTEN inhibitor -
Description
Selective PTEN inhibitor -
Alternative names
- PTP Inhibitor XIX
-
Purity
> 98% -
CAS Number
345630-40-2 -
Chemical structure
Properties
-
Chemical name
N-(9,10-Dioxophenanthren-2-yl)-2,2-dimethylpropanamide -
Molecular weight
307.35 -
Molecular formula
C19H17NO3 -
PubChem identifier
9926586 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(C)(C)C(=O)Nc1ccc2c(c1)C(=O)C(=O)c3ccccc23 -
Source
Synthetic
-
Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab141303 has been referenced in 5 publications.
- Ha SE et al. Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-?B Signaling through PTEN Activation in Hepatocellular Carcinoma. Int J Mol Sci 22:N/A (2021). PubMed: 34445559
- Wang P et al. Inhibition of microRNA-149 protects against recurrent miscarriage through upregulating RUNX2 and activation of the PTEN/Akt signaling pathway. J Obstet Gynaecol Res N/A:N/A (2020). PubMed: 32939872
- Xu F et al. Pectolinarigenin inhibits non-small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep 40:3458-3468 (2018). PubMed: 30542737
- Pan YG et al. FceRI ?-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells. Front Immunol 8:1424 (2017). PubMed: 29163499
- Kälin S et al. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab 26:475-492.e7 (2017). PubMed: 28877454