Anti-SFRS7/SRSF7 antibody (ab138022)

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Western blot - Anti-SFRS7/SRSF7 antibody (ab138022)

    Key features and details

    • Rabbit polyclonal to SFRS7/SRSF7
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-SFRS7/SRSF7 antibody
      See all SFRS7/SRSF7 primary antibodies

    • Description

      Rabbit polyclonal to SFRS7/SRSF7

    • Host species

      Rabbit

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse

    • Immunogen

      Synthetic peptide corresponding to Human SFRS7/SRSF7 (internal sequence).

    • Positive control

      • HT29 cell lysate

    • General notes

       This product was previously labelled as SFRS7

       

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab138022 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB 1/500 - 1/1000. Predicted molecular weight: 27 kDa.

    Target

    • Function

      Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10.

    • Tissue specificity

      Brain, liver, kidney and lung.

    • Sequence similarities

      Belongs to the splicing factor SR family.
      Contains 1 CCHC-type zinc finger.
      Contains 1 RRM (RNA recognition motif) domain.

    • Post-translational
      modifications

      Extensively phosphorylated on serine residues in the RS domain.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    • Database links

      • Alternative names

        • 9G8 antibody
        • AAG3 antibody
        • arginine/serine-rich 7 antibody
        • HSSG1 antibody
        • RBM37 antibody
        • Serine/arginine-rich splicing factor 7 antibody
        • Splicing factor 9G8 antibody
        • Splicing factor antibody
        • Splicing factor, arginine/serine rich 7 antibody
        • SRSF7 antibody
        • SRSF7_HUMAN antibody
        • ZCCHC20 antibody
        • ZCRB2 antibody
        see all

      Images

      • Western blot - Anti-SFRS7/SRSF7 antibody (ab138022)
        Western blot - Anti-SFRS7/SRSF7 antibody (ab138022)
        Anti-SFRS7/SRSF7 antibody (ab138022) at 1/500 dilution + HT29 cell lysate at 30 µg

        Predicted band size: 27 kDa

      References (2)

      Publishing research using ab138022? Please let us know so that we can cite the reference in this datasheet.

      ab138022 has been referenced in 2 publications.

      • Tang SJ  et al. Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development. Nat Commun 11:799 (2020). PubMed: 32034135
      • Llorian M  et al. The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators. Nucleic Acids Res 44:8933-8950 (2016). WB ; Mouse . PubMed: 27317697

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