Overview

  • Product name

  • Description

    Rabbit polyclonal to SFTPA1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human SFTPA1.
    Database link: Q8IWL2

  • Positive control

    • Mouse lung tissue lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab180865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 26 kDa.

Target

  • Function

    In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
  • Involvement in disease

    Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease.
    Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:267450]; also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.
  • Sequence similarities

    Belongs to the SFTPA family.
    Contains 1 C-type lectin domain.
    Contains 1 collagen-like domain.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix. Secreted > extracellular space > surface film.
  • Information by UniProt
  • Database links

  • Alternative names

    • 35 kDa pulmonary surfactant associated protein antibody
    • 35 kDa pulmonary surfactant-associated protein antibody
    • Alveolar proteinosis protein antibody
    • COLEC4 antibody
    • Collectin 4 antibody
    • Collectin-4 antibody
    • FLJ50593 antibody
    • FLJ51913 antibody
    • FLJ61144 antibody
    • FLJ77898, antibody
    • FLJ79095 antibody
    • FLJ99559 antibody
    • MGC133365 antibody
    • MGC198590 antibody
    • OTTHUMP00000019928 antibody
    • OTTHUMP00000019929 antibody
    • OTTHUMP00000019930 antibody
    • OTTHUMP00000019931 antibody
    • PSAP antibody
    • PSP A antibody
    • PSP-A antibody
    • PSPA antibody
    • pulmonary surfactant -associated protein, 35-KD antibody
    • pulmonary surfactant apoprotein PSP-A antibody
    • pulmonary surfactant associated protein A1 antibody
    • Pulmonary surfactant-associated protein A1 antibody
    • SFTA1_HUMAN antibody
    • SFTP1 antibody
    • SFTPA1 antibody
    • SFTPA1B antibody
    • SP A antibody
    • SP A1 antibody
    • SP-A antibody
    • SP-A1 antibody
    • SPA antibody
    • SPA1 antibody
    • surfactant protein A1 antibody
    • surfactant protein A1 variant AB'D' 6A2 antibody
    • surfactant protein A1 variant AB'D' 6A3 antibody
    • surfactant protein A1 variant AB'D' 6A4 antibody
    • surfactant protein A1 variant ACD' 6A2 antibody
    • surfactant protein A1 variant ACD' 6A3 antibody
    • surfactant protein A1 variant ACD' 6A4 antibody
    • surfactant protein A1 variant AD' 6A antibody
    • surfactant protein A1 variant AD' 6A2 antibody
    • surfactant protein A1 variant AD' 6A3 antibody
    • surfactant protein A1 variant AD' 6A4 antibody
    • surfactant protein A1B antibody
    • surfactant, pulmonary associated protein A1A antibody
    • surfactant, pulmonary associated protein A1B antibody
    • surfactant-associated protein, pulmonary 1 antibody
    see all

Images

  • Anti-SFTPA1 antibody (ab180865) at 1/500 dilution + Mouse lung tissue lysate

    Predicted band size: 26 kDa

References

This product has been referenced in:

  • Kook S  et al. Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice. J Biol Chem 291:8414-27 (2016). Read more (PubMed: 26907692) »
See 1 Publication for this product

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