Overview

  • Product name
  • Description
    Rabbit polyclonal to SGCE
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ICC/IF, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment corresponding to Human SGCE (N terminal).
    Database link: O43556

  • Positive control
    • SW620, A549, ES2, 22RV-1 and mouse lung extracts; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab196749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
IHC-P 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 50 kDa.

Target

  • Function
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in SGCE are a cause of dystonia type 11 (DYT11) [MIM:159900]; also known as myoclonic dystonia or alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • Sequence similarities
    Belongs to the sarcoglycan alpha/epsilon family.
  • Cellular localization
    Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • dystonia 11, myoclonic antibody
    • DYT11 antibody
    • Epsilon sarcoglycan antibody
    • Epsilon SG antibody
    • Epsilon-sarcoglycan antibody
    • Epsilon-SG antibody
    • ESG antibody
    • sarcoglycan, epsilon antibody
    • sgcE antibody
    • SGCE_HUMAN antibody
    see all

Images

  • All lanes : Anti-SGCE antibody (ab196749) at 1/500 dilution

    Lane 1 : SW620 cell extract
    Lane 2 : A549 cell extract
    Lane 3 : ES2 cell extract
    Lane 4 : 22RV-1 cell extract
    Lane 5 : Mouse lung extract

    Predicted band size: 50 kDa

  • Immunofluorescent analysis of HeLa cells labeling SGCE with ab196749 at 1/50 dilution. Blue: DAPI for nuclear staining.

References

ab196749 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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