Product nameAnti-SGCE antibody
See all SGCE primary antibodies
DescriptionRabbit polyclonal to SGCE
Tested applicationsSuitable for: ICC/IF, IHC-P, WBmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Recombinant fragment corresponding to Human SGCE (N terminal).
Database link: O43556
- SW620, A549, ES2, 22RV-1 and mouse lung extracts; HeLa cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS, 0.87% Sodium chloride
PBS without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab196749 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/50 - 1/200.|
|IHC-P||1/50 - 1/200.|
|WB||1/500 - 1/2000. Predicted molecular weight: 50 kDa.|
FunctionComponent of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Involvement in diseaseDefects in SGCE are a cause of dystonia type 11 (DYT11) [MIM:159900]; also known as myoclonic dystonia or alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
Sequence similaritiesBelongs to the sarcoglycan alpha/epsilon family.
Cellular localizationCell membrane > sarcolemma. Cytoplasm > cytoskeleton.
- Information by UniProt
- dystonia 11, myoclonic antibody
- DYT11 antibody
- Epsilon sarcoglycan antibody
All lanes : Anti-SGCE antibody (ab196749) at 1/500 dilution
Lane 1 : SW620 cell extract
Lane 2 : A549 cell extract
Lane 3 : ES2 cell extract
Lane 4 : 22RV-1 cell extract
Lane 5 : Mouse lung extract
Predicted band size: 50 kDa
Immunofluorescent analysis of HeLa cells labeling SGCE with ab196749 at 1/50 dilution. Blue: DAPI for nuclear staining.
ab196749 has not yet been referenced specifically in any publications.